CYP4Z1 Information & CYP4Z1 Links at HealthHaven.com

cytochrome P450, family 4, subfamily Z, polypeptide 1
Identifiers
Symbol	CYP4Z1
Entrez	199974
HUGO	20583
RefSeq	NM_178134
UniProt	Q86W10
Other data
Locus	Chr. 1 p33

CYP4Z1 (cytochrome P450, family 4, subfamily Z, polypeptide 1) is a protein which in humans is encoded by the CYP4Z1 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.^[2]

CYP4Z1 is overexpressed in breast cancer cells.^[1] It has also been demonstrated that the expression of the CYP4Z1 gene is upregulated by activated glucocorticoid and progesterone receptors.^[3]

[edit] References

^ ^a ^b Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, Weigle B (April 2004). "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma". Cancer Res. 64 (7): 2357–64. doi:10.1158/0008-5472.CAN-03-0849. PMID 15059886.
^ "Entrez Gene: CYP4Z1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199974.
^ Savas U, Hsu MH, Griffin KJ, Bell DR, Johnson EF (April 2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/j.abb.2005.02.022. PMID 15797250.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid15059886-0] Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, Weigle B (April 2004). "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma". Cancer Res. 64 (7): 2357–64. doi:10.1158/0008-5472.CAN-03-0849. PMID 15059886.

[entrez_2532-1] "Entrez Gene: CYP4Z1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199974.

[pmid15797250-2] Savas U, Hsu MH, Griffin KJ, Bell DR, Johnson EF (April 2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/j.abb.2005.02.022. PMID 15797250.

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