CD58 Information & CD58 Links at HealthHaven.com

CD58 molecule
Identifiers
Symbol	CD58
Alt. symbols	LFA3
Entrez	965
HUGO	1688
OMIM	153420
RefSeq	NM_001779
UniProt	P19256
Other data
Locus	Chr. 1 p13

CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages.^[1]^[2]

It binds to CD2(aka, LFA-2) ^[3] on T cells and is important in strengthening the adhesion between the T-cells and Professional Antigen Presenting Cells. This adhesion occurs as part of the transitory initial encounters between T-cells and Antigen Presenting Cells before T-cell activation, when T-cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell's "T-cell Receptors" (TCR) are reactive to.

Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis^[4].

[edit] References

^ Barbosa JA, Mentzer SJ, Kamarck ME, Hart J, Biro PA, Strominger JL, Burakoff SJ (April 1986). "Gene mapping and somatic cell hybrid analysis of the role of human lymphocyte function-associated antigen-3 (LFA-3) in CTL-target cell interactions". J. Immunol. 136 (8): 3085–91. PMID 3514752. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=3514752.
^ Wallich R, Brenner C, Brand Y, Roux M, Reister M, Meuer S (1998-03-15). "Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene". J. Immunol. 160 (6): 2862–71. PMID 9510189. http://www.jimmunol.org/cgi/content/abstract/160/6/2862.
^ Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZY, Wagner G, Reinherz EL (June 1999). "Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors". Cell 97 (6): 791–803. doi:10.1016/S0092-8674(00)80790-4. PMID 10380930.
^ Hoppenbrouwers IA, Aulchenko YS, Janssens AC, Ramagopalan SV, Broer L, Kayser M, Ebers GC, Oostra BA, van Duijn CM, Hintzen RQ. (16 October 2009). "Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.". J Hum Genet.. PMID 19834503.

[edit] External links

MeSH CD58+Antigen

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[pmid3514752-0] Barbosa JA, Mentzer SJ, Kamarck ME, Hart J, Biro PA, Strominger JL, Burakoff SJ (April 1986). "Gene mapping and somatic cell hybrid analysis of the role of human lymphocyte function-associated antigen-3 (LFA-3) in CTL-target cell interactions". J. Immunol. 136 (8): 3085–91. PMID 3514752. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=3514752.

[pmid9510189-1] Wallich R, Brenner C, Brand Y, Roux M, Reister M, Meuer S (1998-03-15). "Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene". J. Immunol. 160 (6): 2862–71. PMID 9510189. http://www.jimmunol.org/cgi/content/abstract/160/6/2862.

[pmid10380930-2] Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZY, Wagner G, Reinherz EL (June 1999). "Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors". Cell 97 (6): 791–803. doi:10.1016/S0092-8674(00)80790-4. PMID 10380930.

[3] Hoppenbrouwers IA, Aulchenko YS, Janssens AC, Ramagopalan SV, Broer L, Kayser M, Ebers GC, Oostra BA, van Duijn CM, Hintzen RQ. (16 October 2009). "Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.". J Hum Genet.. PMID 19834503.

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