CD52 is a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found in monocytes[1] and dendritic cells.[2] It is a glycosylphosphatidylinositol (GPI)--anchored antigen expressed on the all lymphocytes as well as within the male genital tract. [edit] Clinical significance It is the protein targeted by alemtuzumab, an antibody used for the treatment of chronic lymphocytic leukemia. It is associated with certain types of lymphoma.[3] [edit] References - ^ Buggins AG, Mufti GJ, Salisbury J, et al. (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood 100 (5): 1715–20. PMID 12176892. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12176892.
- ^ Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12393688.
- ^ Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA (2007). "Expression of CD52 in peripheral T-cell lymphoma". Haematologica 92 (4): 566–7. doi:10.3324/haematol.10767. PMID 17488672.
[edit] External links | Proteins: clusters of differentiation (see also list of human clusters of differentiation) | | | 1-50 | CD1 ( a-c, 1A, 1D, 1E) · CD2 · CD3 ( γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 ( a) · CD9 · CD10 · CD11 ( a, b, c) · CD13 · CD14 · CD15 · CD16 ( A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 ( A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 ( a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 ( a, b, c, d, e, f) · CD50 | | | 51-100 | CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 ( E, L, P) · CD63 · CD64 ( A, B, C) · CD66 ( a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 ( a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 ( a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD97 · CD98 · CD99 · CD100 | | | 101-150 | | | | 151-200 | CD151 · CD152 · CD153 · CD154 · CD155 · CD156 ( a, b, c) · CD157 · CD158 ( a, d, e, i, k) · CD159 ( a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 ( a, b) · CD168 · CD169 · CD170 · CD171 · CD172 ( a, b, g) · CD174 · CD177 · CD178 · CD179 ( a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200 | | | 201-250 | | | | 251-300 | | | | 301-350 | | |
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