Integrin alpha M Information & Integrin alpha M Links at HealthHaven.com

Integrin, alpha M (complement component 3 receptor 3 subunit)
	; PDB rendering based on 1bho.
Available structures
	1bho, 1bhq, 1idn, 1ido, 1jlm, 1m1u, 1mf7, 1n9z, 1na5
Identifiers
Symbols	ITGAM; CD11B; CR3A; MAC-1; MAC1A; MGC117044; MO1A
External IDs	OMIM: 120980 MGI: 96607 HomoloGene: 526 GeneCards: ITGAM Gene
Gene ontology
Molecular function	• magnesium ion binding; • opsonin binding; • glycoprotein binding; • receptor activity; • calcium ion binding; • protein binding;
Cellular component	• nucleus; • integrin complex; • external side of plasma membrane; • membrane; • integral to membrane;
Biological process	• cell adhesion; • integrin-mediated signaling pathway; • neutrophil chemotaxis; • cellular extravasation; • activated T cell proliferation;
RNA expression pattern
	More reference expression data
Orthologs

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Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (α_Mβ₂) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3).^[1] ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of α_Mβ₂ is the common integrin β₂ subunit known as CD18, and integrin α_Mβ₂ thus belongs to the β₂ subfamily (or leukocyte) integrins.^[2]

α_Mβ₂ is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells.^[1] It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation.^[1] It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b).^[3] The ITGAM (alpha) subunit of integrin α_Mβ₂ is directly involved in causing the adhesion and spreading of cells but cannot mediate cellular migration without the presence of the β2 (CD18) subunit.^[1]

In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with systemic lupus erythematosus, with an odds ratio of 1.65 for the T allele of rs9888739 and lupus.^[4]^[5]

[edit] See also

integrin

[edit] References

^ ^a ^b ^c ^d Solovjov D, Pluskota E, Plow E (2005). "Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2". J Biol Chem 280 (2): 1336–45. doi:10.1074/jbc.M406968200. PMID 15485828.
^ Larson R, Springer T (1990). "Structure and function of leukocyte integrins". Immunol Rev 114: 181–217. doi:10.1111/j.1600-065X.1990.tb00565.x. PMID 2196220.
^ Arnaout M, Todd R, Dana N, Melamed J, Schlossman S, Colten H (1983). "Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)". J Clin Invest 72 (1): 171–9. doi:10.1172/JCI110955. PMID 6874946.
^ Mary K. Crow (February 28, 2008). "Collaboration, Genetic Associations, and Lupus Erythematosus". N Engl J Med 358 (9): 956–961. doi:10.1056/NEJMe0800096. PMID 18204099. http://content.nejm.org/cgi/content/full/358/9/956.
^ Geoffrey Hom, Robert R. Graham, Barmak Modrek, et al. (February 28, 2008). "Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX". N Engl J Med 358 (9): 900–909. doi:10.1056/NEJMoa0707865. PMID 18204098. http://content.nejm.org/cgi/content/full/358/9/900.

[edit] Further reading

Stewart M, Thiel M, Hogg N (1996). "Leukocyte integrins.". Curr. Opin. Cell Biol. 7 (5): 690–6. doi:10.1016/0955-0674(95)80111-1. PMID 8573344.
Todd RF, Petty HR (1997). "Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors.". J. Lab. Clin. Med. 129 (5): 492–8. doi:10.1016/S0022-2143(97)90003-2. PMID 9142045.
Schymeinsky J, Mócsai A, Walzog B (2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications.". Thromb. Haemost. 98 (2): 262–73. PMID 17721605.

[edit] External links

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[solov-0] Solovjov D, Pluskota E, Plow E (2005). "Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2". J Biol Chem 280 (2): 1336–45. doi:10.1074/jbc.M406968200. PMID 15485828.

[1] Larson R, Springer T (1990). "Structure and function of leukocyte integrins". Immunol Rev 114: 181–217. doi:10.1111/j.1600-065X.1990.tb00565.x. PMID 2196220.

[2] Arnaout M, Todd R, Dana N, Melamed J, Schlossman S, Colten H (1983). "Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)". J Clin Invest 72 (1): 171–9. doi:10.1172/JCI110955. PMID 6874946.

[3] Mary K. Crow (February 28, 2008). "Collaboration, Genetic Associations, and Lupus Erythematosus". N Engl J Med 358 (9): 956–961. doi:10.1056/NEJMe0800096. PMID 18204099. http://content.nejm.org/cgi/content/full/358/9/956.

[4] Geoffrey Hom, Robert R. Graham, Barmak Modrek, et al. (February 28, 2008). "Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX". N Engl J Med 358 (9): 900–909. doi:10.1056/NEJMoa0707865. PMID 18204098. http://content.nejm.org/cgi/content/full/358/9/900.

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Contents

[edit] See also

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[edit] Further reading

[edit] External links