complement component 4 binding protein, alpha
Identifiers
Symbol	C4BPA
Alt. symbols	C4BP
Entrez	722
HUGO	1325
OMIM	120830
RefSeq	NM_000715
UniProt	P04003
Other data
Locus	Chr. 1 q32

complement component 4 binding protein, beta
Identifiers
Symbol	C4BPB
Alt. symbols	C4BP
Entrez	725
HUGO	1328
OMIM	120831
RefSeq	NM_000716
UniProt	P20851
Other data
Locus	Chr. 1 q32

C4BP is a protein involved in the complement system. C4BP has a hydra-like structure with a central stalk and seven branching alpha-chains.

[edit] Functions

It inhibits the action of C4, more specifically the classical pathway. It splits C4 convertase and is a cofactor for factor I which cleaves C4b.

C4BP binds necrotic cells and DNA, to clean up after swelling.

It also binds CD40 on B cells which potentiaties proliferation and costimulation.

[edit] External links

• MeSH Complement+C4b-Binding+Protein

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Proteins: complement system (C, L, A) Activators/enzymes Early C: C1Q/C1R/C1S - C4 (C4a) - C2 L: MASP1/MASP2 - MBL Middle CLA: C3 (C3a, C3b/iC3b) - C5 (C5a) A: Factor B - Factor D - Factor P/Properdin CLA: C3-convertase - C5-convertase Late CLA: MAC (C6, C7, C8, C9) Inhibitors CLA: C1-inhibitor - Decay accelerating factor - Factor I CL: C4BP A: Factor H Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)