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Blepharitis (pronounced /blɛfərˈaɪtɨs/ BLEF-ər-EYE-tis) is an ocular disease characterized by inflammation of the eyelid margins. Blepharitis may cause redness of the eyes, itching and irritation of the eyelids in one or both eyes. Its appearance is often confused with conjunctivitis and due to its recurring nature it is the most common cause of "recurrent conjunctivitis" in older people. It is also often mistaken for "dry eye" by patients due to the gritty sensation that may occur, however lubricating drops do little to improve the condition.

[edit] Classification

There are two types of blepharitis:

[edit] Seborrhoeic blepharitis

Seborrhoeic blepharitis, the most common type of blepharitis,^{[citation needed]} is usually one part of the spectrum of seborrhoeic dermatitis which involves the scalp, lashes, eyebrows, nasolabial folds and ears. Treatment is best accomplished by a dermatologist.

[edit] Staphylococcal blepharitis

Staphlycoccal blepharitis is caused by infection of the anterior portion of the eyelid by Staphylococcal bacteria. As the infection progresses, the sufferer may begin to notice a foreign body sensation, matting of the lashes, and burning. Usually, the primary care physician will prescribe topical antibiotics for staphylococcal blepharitis. Unfortunately this is rarely an effective treatment.^{[citation needed]} The condition can sometimes lead to a chalazion or a stye.^[1]

[edit] Posterior blepharitis or rosacea-associated blepharitis

The most common type of blepharitis is often found in people with a Rosacea skin type.^{[citation needed]} The oil glands in the lid of rosacea sufferers secrete a modified oil which leads to inflammation at the gland openings which are found at the edge of the lid.^{[citation needed]}

[edit] Treatment and management

The single most important treatment principle is a daily routine of lid margin hygiene, as described below. Such a routine needs to be convenient enough to be continued for life to avoid relapses as blepharitis is often a chronic condition. But it can be acute, and one episode does not mean it is a life-long condition.

A typical lid margin hygiene routine consists of four steps:

1. Softening of lid margin debris and oils: Apply a warm wet compress to the lids - such as a washcloth with hot water - for about two minutes. New, dry, warm compress masks can be conveniently warmed in a micro-wave oven and maintain a comfortable 40C temperature for 10 minutes while the waxy oils blocking the glands are cleared.
2. Mechanical removal of lid margin debris: At the end of a shower routine, wash your face with a wash cloth. Use facial soap or non-burning baby shampoo (make sure to dilute the soap solution 1/10 with water first). Gently and repeatedly rub along the lid margins while eyes are closed. Too much soap or shampoo may remove the essential oily layer of the eyes' own tear film and create further problems with dry eye discomfort.
3. Antibiotic reduction of lid margin bacteria (at the discretion of your physician): After lid margin cleaning, spread small amount of prescription antibiotic ophthalmic ointment with finger tip along lid fissure while eyes closed. Use prior to bed time as opposed to in the morning to avoid blurry vision.
4. Avoid the use of eye make-up until symptoms subside.

An alternative after washing is to coat the eyelids with a good quality hair conditioner. Leave in place for several minutes then rinse. The conditioner seems to break the bacteria / crusting /irritation cycle, and daily use can eliminate the symptoms.

The following guide is very common but is more challenging to perform by visually disabled or frail patients as it requires good motor skills and a mirror. Compared with the above, it does not bear any advantages:

1. Apply hot compresses to both eyes for five minutes once to twice per day. The "hot wet flannel" treatment is often recommended, however this does not stay hot for long enough, is very messy & potentially unhygienic. A very effective alternative is the flax filled mask which is heated in a microwave oven - try the Warm Compress Mask from LUMECARE.
2. After hot compresses, in front of a mirror, use a moist Q-tip soaked in a cup of water with a drop of baby shampoo, or a drop of antibiotic such as Chloramphenicol. Rub along the lid margins while tilting the lid outward with the other hand.
3. In front of mirror, place small drop of antibiotic ophthalmic ointment (e.g. erythromycin) in lower conjunctival sac while pulling lid away from eye with other hand.

Often the above is advised together with mild massage to mechanically empty glands located at the lid margin (Meibomian glands, Zeis glands, Moll glands).^[2]

Depending on the degree of inflammation of the lid margin, a combination of topical antibiotic and steroid drops or ointments can be prescribed to provide instant relief. However, this harbors significant risks such as increased intraocular pressure and posterior subcapsular cataract formation.^{[citation needed]} Since cataract formation is irreversible and even intraocular hypertension might be (harbouring the risk of glaucoma with permanent visual loss), both need to be checked for monthly. Steroid-induced cataracts and ocular hypertension can affect all ages.^{[citation needed]}

If acne rosacea coexists, treatment should be focused on this skin disorder as the underlying cause together with the above lid margin hygiene routine. Typically, 100 mg doxycycline by mouth twice per day is prescribed for four to six weeks which can be tapered to 50 mg once daily for several years. Some physicians use a lower starting dose. Patients are instructed to continue use for at least two months before symptoms improve significantly. Contrary to common belief, use of tetracycline-type antibiotics is not primarily to treat bacterial infection but rather to inhibit matrix metalloproteinases resulting in thinning of oil gland secretions and change of the characteristic prominent capillary pattern. Long-term use can result in pseudomembranous colitis, and patients must be warned of possible symptoms of C. Difficile infection.

Dermatologists treat blepharitis similarly to seborrhoeic dermatitis by using a safe topical anti-inflammatory medication like sulfacetamide or brief courses of a mild topical steroid. Although anti-fungals like ketoconazole (Nizoral) are commonly prescribed for seborrhoeic dermatitis, dermatologists and optometrists usually do not prescribe anti-fungals for seborrhoeic blepharitis.^[3]

If these conventional treatments for blepharitis do not bring relief, patients may consider allergy testing and ocular antihistamines. Allergic responses to dust mite feces and other allergens can cause lid inflammation, ocular irritation, and dry eyes. Prescription ocular antihistamines and over-the-counter ocular antihistamines are very safe and can bring almost immediate relief to patients whose lid inflammation is caused by allergies.

[edit] See also

• Seborrhoeic dermatitis
• List of skin diseases
• List of eye diseases and disorders
• Stye
• Chalazion
• Conjunctivitis

[edit] External links

• Blepharitis Resource Guide from the National Eye Institute (NEI).
• Mayo Clinic
• Blepharitis description from the American Optometric Association
• eMedicine Health: Eyelid Inflammation (Blepharitis)
• Blepharitis Fact Sheet

[edit] References