Structure of gram-negative cell envelope

The bacterial outer membrane is found in Gram-negative bacteria. Its composition is distinct from that of the cytoplasmic membrane - among other things, the outer leaflet of the membrane include a complex lipopolysaccharide whose lipid portion acts as an endotoxin - and it is linked to the cell's peptidoglycan by Braun's lipoprotein.

Porins can be found in this layer.^[1]

[edit] Clinical significance

If endotoxin enters the circulatory system it causes a toxic reaction with the sufferer having a high temperature and respiration rate and a low blood pressure. This may lead to endotoxic shock, which may be fatal.

[edit] References