Waterhyssop
Bacopa monnieri
Scientific classification
Kingdom:	Plantae
(unranked):	Angiosperms
(unranked):	Eudicots
(unranked):	Asterids
Order:	Lamiales
Family:	Plantaginaceae
Genus:	Bacopa Aubl.

Bacopa is a genus of 70 - 100 aquatic plants belonging to the family Plantaginaceae. It is commonly known as Waterhyssop (or Water Hyssop, though this is more misleading as Bacopa is not very closely related to hyssop but simply has a somewhat similar habitus).

Contents 1 Description 2 Uses 2.1 Neurochemical effects 3 Clinical Studies 4 Anxiety 5 Species 6 Confusion with 7 Cultivation 8 See also 9 References 10 External links

[edit] Description

They are annual or perennial, decumbent or erect stemmed plants. The leaves are opposite or whorled, sessile. Leaf blade regular, round to linear, venation palmate or pinnate. Stems hairy or smooth. The flowers are produced solitary or in pairs from leaf axil, usually radially symmetrical, sepals 5, petals 5, usually white, blue or purple in color. Dispersal and propagation is by seeds and stem fragments. Crushed leaves have a distinctive 'lemon' scent.

[edit] Uses

B. monnieri syn. Herpestis monniera, is important in ayurvedic medicine and has been used, particularly in India, for several thousand years.It has been identified as brahmi, which is considered medhya rasayan a "brain tonic", supposedly enhancing memory development, learning, and concentration. ^[1] Earlier, in Ayurvedic literature B. monnieri was identified as jal brahmi or jal neem and Centella asiatica was considered brahmi (Puri,2003).

The herb shows significant psychotropic action as evidenced by excessive sleep and conformation changes in the brain as well as blood. It has anticancerous and antioxidant effect also.^[2]

Its many active compounds include: alkaloids (brahmine and herpestine), saponins (d-mannitol and hersaponin, acid A, and monnierin), flavonoids (luteolin and apigenin). Also in significant amounts: betulic acid, stigmastarol, beta-sitosterol, bacopasaponins (bacosides A, bacosides B, bacopaside II, bacopaside I, bacopaside X, bacopasaponin C, bacopaside N2 and the minor components were bacopasaponin F, bacopasaponin E, bacopaside N1, bacopaside III, bacopaside IV, and bacopaside V).

[edit] Neurochemical effects

• Bacosides A:
  • Enhances the body’s antioxidant defenses (increases superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities)^[3]
  • Maintains the structural and functional integrity of the mitochondrial membrane (by inhibiting excessive lipid peroxidation & creatine kinase, improving the activities of ATPases, and maintaining the ionic equilibrium.)(PMID 16050806)
  • Protects gastrointestinal health (by raising mucosal defensive factors)^{[citation needed]}
• Bacopasaponin C:
  • Has an inhibitory effect against parasites (anti-leishmanial properties)^{[citation needed]}

• B. monnieri has a demonstrated ability to reverse diazepam-induced amnesia in the Morris water maze test. The mechanism of this action is unknown. ^[4]

Further Reading:

Puri, H.S. (2003) RASAYANA: Ayurvedic Herbs for Longevity and Rejuvenation. Taylor & Francis, London, pages.94-97

[edit] Clinical Studies

In two studies, approx. 80 middle-aged and older adults took 300 mg of bacopacides extracted from Bacopa monieri per day for four to six weeks. The results of the studies showed that bacopa did little or nothing for restoring or enhancing their previous memories, but enhanced the retention of new information significantly.^[5][6]

[edit] Anxiety

A 1998 study involving rats who were given a 25% bacoside A dose of Bacopa extract showed that anxiolytic activity was enhanced as much as if the drug lorazepam were administered. The treatment with Bacopa extract exhibited none of the side effects of Lorazepam, such as amnesia^[7]

[edit] Species

The species in the Bacopa genus include:

• Bacopa australis
• Bacopa caroliniana (lemon bacopa, blue water hyssop, giant bacopa)
• Bacopa crenata
• Bacopa eisenii
• Bacopa madagascariensis
• Bacopa monnieri (water hyssop, moneywort, herb of grace)
• Bacopa myriophylloides
• Bacopa rotundifolia

and are found in tropical and subtropical regions of the world, particularly America. A few are regarded as weeds and excess stock should not be dumped in warmer regions. Most grow in moist amphibious conditions, though some like B. myriophylloides seem to be wholly aquatic.

[edit] Confusion with

A South African ground cover plant sometimes sold in garden centres as Bacopa ‘Snowflake’ (white flowers) or ’Blue Showers’ (blue flowers) - or other similar names - are actually varieties of Sutera cordata a tender perennial.

[edit] Cultivation

Some of these species are commonly used in freshwater aquariums and around and in ponds in warmer climes. Most are easy to grow and are slow-growing, but require medium to high amounts of light. Most are easy to grow and will tolerate a wide range of water conditions. B. caroliniana at least will tolerate brackish water. Plants are usually best planted in groups in the middle to background. Algal infestation can be a problem in brighter lighting conditions.

[edit] See also

• Sutera 'Cabana', a plant also known by the obsolete name Bacopa 'Cabana'.

[edit] References

Wikimedia Commons has media related to: Bacopa

1. ^ Keeping the Mind Finely Tuned Earlier, Bacopa Protects Your Brain from Aluminum-Induced Damage
2. ^ Botanical.com
3. ^ Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats By K Anbarsi et al. Life Science Vol 78 Issue 12 Feb 2006
4. ^ Kumar Saraf, M., Prabhakar, S., Pandhi, P., Anand, A., Bacopa monniera ameliorates amnesic effects of Diazepam qualifying behavioral- molecular partitioning, Neuroscience (2008), doi=10.1016/j.neuroscience.2008.05.043
5. ^ Roodenrys, Steven Ph.D., et al. (2002). "Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory". Neuropsychopharmacology 27: 279–281. doi:10.1016/S0893-133X(01)00419-5. 
6. ^ Nathan, PJ, et al. (2004). "Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans". Hum. Psychopharmacol. 19: 91–96. doi:10.1002/hup.544. 
7. ^ Ghosal. S, Bhattacharya SK (1980). "Anxiolytic activity of a standardized extract of Bacopa monniera in an experimental study". Phytomedicine 5: 133–148. 

[edit] External links

• Bacopa Monograph By Dr Ajay Padmawar
• Bramhi
• NYU Medical fact sheets with literature refs
• Bacopa
• Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment