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B-cell CLL/lymphoma 10
Identifiers
Symbols	BCL10; CARMEN; CIPER; CLAP; c-E10; mE10
External IDs	OMIM: 603517 MGI: 1337994 HomoloGene: 2912
Gene ontology
Molecular function	• transcription coactivator activity; • protein C-terminus binding; • kinase activator activity; • ubiquitin protein ligase binding; • ubiquitin binding; • protein kinase B binding; • protein self-association; • NF-kappaB binding;
Cellular component	• intracellular; • nucleus; • cytoplasm; • lysosome; • cytosol; • CBM complex; • T cell receptor complex; • lipid raft; • lipopolysaccharide receptor complex; • perinuclear region of cytoplasm;
Biological process	• toll-like receptor signaling pathway; • response to molecule of bacterial origin; • adaptive immune response; • negative regulation of mature B cell apoptosis; • cell cycle; • I-kappaB kinase/NF-kappaB cascade; • cell death; • immunoglobulin mediated immune response; • positive regulation of protein ubiquitination; • positive regulation of mast cell cytokine production; • lymphotoxin A biosynthetic process; • response to chemical stimulus; • interleukin-6 biosynthetic process; • positive regulation of phosphorylation; • regulation of apoptosis; • positive regulation of I-kappaB kinase/NF-kappaB cascade; • innate immune response; • positive regulation of interleukin-8 biosynthetic process; • negative regulation of progression through cell cycle; • positive regulation of transcription, DNA-dependent; • T cell receptor signaling pathway; • activation of NF-kappaB transcription factor; • protein homooligomerization;
Orthologs
NP_003912 (protein)	NP_033870 (protein)

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B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.^[1]^[2]

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.^[2]

[edit] Interactions

BCL10 has been shown to interact with CARD10,^[3] CARD11,^[4] MALT1,^[5] TRAF2,^[6] IKBKG^[7] and CARD9.^[8]

[edit] References

^ Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ (Mar 1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell 96 (1): 35–45. PMID 9989495.
^ ^a ^b "Entrez Gene: BCL10 B-cell CLL/lymphoma 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915.
^ Wang, L; Guo Y, Huang W J, Ke X, Poyet J L, Manji G A, Merriam S, Glucksmann M A, DiStefano P S, Alnemri E S, Bertin J (Jun. 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. (United States) 276 (24): 21405–9. doi:10.1074/jbc.M102488200. ISSN 0021-9258. PMID 11259443.
^ Bertin, J; Wang L, Guo Y, Jacobson M D, Poyet J L, Srinivasula S M, Merriam S, DiStefano P S, Alnemri E S (Apr. 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. (United States) 276 (15): 11877–82. doi:10.1074/jbc.M010512200. ISSN 0021-9258. PMID 11278692.
^ Uren, A G; O'Rourke K, Aravind L A, Pisabarro M T, Seshagiri S, Koonin E V, Dixit V M (Oct. 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell (United States) 6 (4): 961–7. ISSN 1097-2765. PMID 11090634.
^ Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (Apr. 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. (UNITED STATES) 275 (15): 11114–20. ISSN 0021-9258. PMID 10753917.
^ Wu, Chuan-Jin; Ashwell Jonathan D (Feb. 2008). "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (8): 3023–8. doi:10.1073/pnas.0712313105. PMID 18287044.
^ Bertin, J; Guo Y, Wang L, Srinivasula S M, Jacobson M D, Poyet J L, Merriam S, Du M Q, Dyer M J, Robison K E, DiStefano P S, Alnemri E S (Dec. 2000). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. (UNITED STATES) 275 (52): 41082–6. doi:10.1074/jbc.C000726200. ISSN 0021-9258. PMID 11053425.

[edit] Further reading

Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma.". Hematol. J. 3 (1): 10–3. doi:10.1038/sj/thj/6200146. PMID 11960389.
Lee WC, Balsara B, Liu Z, et al. (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma.". Cancer Res. 56 (19): 4297–301. PMID 8813110.
Koseki T, Inohara N, Chen S, et al. (1999). "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.". J. Biol. Chem. 274 (15): 9955–61. doi:10.1074/jbc.274.15.9955. PMID 10187770.
Thome M, Martinon F, Hofmann K, et al. (1999). "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.". J. Biol. Chem. 274 (15): 9962–8. doi:10.1074/jbc.274.15.9962. PMID 10187771.
Yan M, Lee J, Schilbach S, et al. (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic molecule.". J. Biol. Chem. 274 (15): 10287–92. doi:10.1074/jbc.274.15.10287. PMID 10187815.
Zhang Q, Siebert R, Yan M, et al. (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).". Nat. Genet. 22 (1): 63–8. doi:10.1038/8767. PMID 10319863.
Srinivasula SM, Ahmad M, Lin JH, et al. (1999). "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.". J. Biol. Chem. 274 (25): 17946–54. doi:10.1074/jbc.274.25.17946. PMID 10364242.
Apostolou S, De Rienzo A, Murthy SS, et al. (1999). "Absence of BCL10 mutations in human malignant mesothelioma.". Cell 97 (6): 684–6; discussion 686–8. doi:10.1016/S0092-8674(02)09765-9. PMID 10380921.
Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB.". J. Biol. Chem. 274 (29): 20127–32. doi:10.1074/jbc.274.29.20127. PMID 10400625.
Yoneda T, Imaizumi K, Maeda M, et al. (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein.". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917.
Ye H, Dogan A, Karran L, et al. (2000). "BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.". Am. J. Pathol. 157 (4): 1147–54. PMID 11021819.
Bertin J, Guo Y, Wang L, et al. (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.". J. Biol. Chem. 275 (52): 41082–6. doi:10.1074/jbc.C000726200. PMID 11053425.
Uren AG, O'Rourke K, Aravind LA, et al. (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.". Mol. Cell 6 (4): 961–7. PMID 11090634.
Poyet JL, Srinivasula SM, Alnemri ES (2001). "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.". J. Biol. Chem. 276 (5): 3183–7. doi:10.1074/jbc.C000792200. PMID 11113112.
Ruland J, Duncan GS, Elia A, et al. (2001). "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.". Cell 104 (1): 33–42. doi:10.1016/S0092-8674(01)00189-1. PMID 11163238.
Wang L, Guo Y, Huang WJ, et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
Lucas PC, Yonezumi M, Inohara N, et al. (2001). "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.". J. Biol. Chem. 276 (22): 19012–9. doi:10.1074/jbc.M009984200. PMID 11262391.
Bertin J, Wang L, Guo Y, et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
Gaide O, Martinon F, Micheau O, et al. (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.". FEBS Lett. 496 (2-3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid9989495-0] Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ (Mar 1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell 96 (1): 35–45. PMID 9989495.

[entrez-1] "Entrez Gene: BCL10 B-cell CLL/lymphoma 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915.

[pmid11259443-2] Wang, L; Guo Y, Huang W J, Ke X, Poyet J L, Manji G A, Merriam S, Glucksmann M A, DiStefano P S, Alnemri E S, Bertin J (Jun. 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. (United States) 276 (24): 21405–9. doi:10.1074/jbc.M102488200. ISSN 0021-9258. PMID 11259443.

[pmid11278692-3] Bertin, J; Wang L, Guo Y, Jacobson M D, Poyet J L, Srinivasula S M, Merriam S, DiStefano P S, Alnemri E S (Apr. 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. (United States) 276 (15): 11877–82. doi:10.1074/jbc.M010512200. ISSN 0021-9258. PMID 11278692.

[pmid11090634-4] Uren, A G; O'Rourke K, Aravind L A, Pisabarro M T, Seshagiri S, Koonin E V, Dixit V M (Oct. 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell (United States) 6 (4): 961–7. ISSN 1097-2765. PMID 11090634.

[pmid10753917-5] Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (Apr. 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. (UNITED STATES) 275 (15): 11114–20. ISSN 0021-9258. PMID 10753917.

[pmid18287044-6] Wu, Chuan-Jin; Ashwell Jonathan D (Feb. 2008). "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (8): 3023–8. doi:10.1073/pnas.0712313105. PMID 18287044.

[pmid11053425-7] Bertin, J; Guo Y, Wang L, Srinivasula S M, Jacobson M D, Poyet J L, Merriam S, Du M Q, Dyer M J, Robison K E, DiStefano P S, Alnemri E S (Dec. 2000). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. (UNITED STATES) 275 (52): 41082–6. doi:10.1074/jbc.C000726200. ISSN 0021-9258. PMID 11053425.

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