BAG1 Information & BAG1 Links at HealthHaven.com

BCL2-associated athanogene
	; PDB rendering based on 1hx1.
Available structures
	1hx1, 1wxv
Identifiers
Symbols	BAG1;
External IDs	OMIM: 601497 MGI: 108047 HomoloGene: 3190 GeneCards: BAG1 Gene
Gene ontology
Molecular function	• receptor signaling protein activity; • protein binding;
Cellular component	• nucleus; • cytoplasm; • cytosol;
Biological process	• protein folding; • protein modification process; • apoptosis; • anti-apoptosis; • cell surface receptor linked signal transduction; • neuron differentiation;
RNA expression pattern
	More reference expression data
Orthologs

edit

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.^[1]

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.^[2]

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.^[3]

[edit] Interactions

BAG1 has been shown to interact with Retinoic acid receptor alpha,^[4] C-Raf,^[5] PPP1R15A,^[6] Androgen receptor,^[7]^[8]^[9] HSPA8,^[10]^[11] Heparin-binding EGF-like growth factor,^[12] Glucocorticoid receptor,^[13]^[14] Calcitriol receptor^[15] and SIAH1.^[16]

[edit] References

^ Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (Mar 1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell 80 (2): 279–84. PMID 7834747.
^ "Entrez Gene: BAG1 BCL2-associated athanogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573.
^ Physorg:Old Cells Work Differently
^ Liu, R; Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K (Jul. 1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. Biol. Chem. (UNITED STATES) 273 (27): 16985–92. ISSN 0021-9258. PMID 9642262.
^ Wang, H G; Takayama S, Rapp U R, Reed J C (Jul. 1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (14): 7063–8. ISSN 0027-8424. PMID 8692945.
^ Hung, Wesley J; Roberson Rachel S, Taft Jaime, Wu Daniel Y (May. 2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. (United States) 23 (10): 3477–86. ISSN 0270-7306. PMID 12724406.
^ Shatkina, Liubov; Mink Sigrun, Rogatsch Hermann, Klocker Helmut, Langer Gernot, Nestl Andrea, Cato Andrew C B (Oct. 2003). "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor". Mol. Cell. Biol. (United States) 23 (20): 7189–97. ISSN 0270-7306. PMID 14517289.
^ Knee, D A; Froesch B A, Nuber U, Takayama S, Reed J C (Apr. 2001). "Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity". J. Biol. Chem. (United States) 276 (16): 12718–24. doi:10.1074/jbc.M010841200. ISSN 0021-9258. PMID 11278763.
^ Froesch, B A; Takayama S, Reed J C (May. 1998). "BAG-1L protein enhances androgen receptor function". J. Biol. Chem. (UNITED STATES) 273 (19): 11660–6. ISSN 0021-9258. PMID 9565586.
^ Takayama, S; Bimston D N, Matsuzawa S, Freeman B C, Aime-Sempe C, Xie Z, Morimoto R I, Reed J C (Aug. 1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70". EMBO J. (ENGLAND) 16 (16): 4887–96. doi:10.1093/emboj/16.16.4887. ISSN 0261-4189. PMID 9305631.
^ Takayama, S; Xie Z, Reed J C (Jan. 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J. Biol. Chem. (UNITED STATES) 274 (2): 781–6. ISSN 0021-9258. PMID 9873016.
^ Lin, J; Hutchinson L, Gaston S M, Raab G, Freeman M R (Aug. 2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation". J. Biol. Chem. (United States) 276 (32): 30127–32. doi:10.1074/jbc.M010237200. ISSN 0021-9258. PMID 11340068.
^ Kullmann, M; Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato A C (Jun. 1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis". J. Biol. Chem. (UNITED STATES) 273 (23): 14620–5. ISSN 0021-9258. PMID 9603979.
^ Schneikert, J; Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato A C (Dec. 2000). "Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor". EMBO J. (ENGLAND) 19 (23): 6508–16. doi:10.1093/emboj/19.23.6508. ISSN 0261-4189. PMID 11101523.
^ Guzey, M; Takayama S, Reed J C (Dec. 2000). "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. Chem. (UNITED STATES) 275 (52): 40749–56. doi:10.1074/jbc.M004977200. ISSN 0021-9258. PMID 10967105.
^ Matsuzawa, S; Takayama S, Froesch B A, Zapata J M, Reed J C (May. 1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1". EMBO J. (ENGLAND) 17 (10): 2736–47. doi:10.1093/emboj/17.10.2736. ISSN 0261-4189. PMID 9582267.

[edit] Further reading

Tang SC (2003). "BAG-1, an anti-apoptotic tumour marker.". IUBMB Life 53 (2): 99–105. doi:10.1080/15216540211473. PMID 12049201.
Clemo NK, Arhel NJ, Barnes JD, et al. (2005). "The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.". Biochem. Soc. Trans. 33 (Pt 4): 676–8. doi:10.1042/BST0330676. PMID 16042572.
Gehring U (2007). "Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms.". Cell Stress Chaperones 11 (4): 295–303. doi:10.1379/1466-1268(2006)11[295:AOTCBA]2.0.CO;2. PMID 17278878.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zeiner M, Gehring U (1996). "A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11465–9. doi:10.1073/pnas.92.25.11465. PMID 8524784.
Wang HG, Takayama S, Rapp UR, Reed JC (1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7063–8. doi:10.1073/pnas.93.14.7063. PMID 8692945.
Takayama S, Kochel K, Irie S, et al. (1996). "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.". Genomics 35 (3): 494–8. doi:10.1006/geno.1996.0389. PMID 8812483.
Bardelli A, Longati P, Albero D, et al. (1997). "HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.". Embo J. 15 (22): 6205–12. PMID 8947043.
Takayama S, Bimston DN, Matsuzawa S, et al. (1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70.". Embo J. 16 (16): 4887–96. doi:10.1093/emboj/16.16.4887. PMID 9305631.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Packham G, Brimmell M, Cleveland JL (1998). "Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.". Biochem. J. 328 ( Pt 3): 807–13. PMID 9396724.
Matsuzawa S, Takayama S, Froesch BA, et al. (1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.". Embo J. 17 (10): 2736–47. doi:10.1093/emboj/17.10.2736. PMID 9582267.
Kullmann M, Schneikert J, Moll J, et al. (1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis.". J. Biol. Chem. 273 (23): 14620–5. doi:10.1074/jbc.273.23.14620. PMID 9603979.
Liu R, Takayama S, Zheng Y, et al. (1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells.". J. Biol. Chem. 273 (27): 16985–92. doi:10.1074/jbc.273.27.16985. PMID 9642262.
Takayama S, Krajewski S, Krajewska M, et al. (1998). "Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.". Cancer Res. 58 (14): 3116–31. PMID 9679980.
Takayama S, Xie Z, Reed JC (1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.". J. Biol. Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
Yang X, Pater A, Tang SC (1999). "Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants.". Oncogene 18 (32): 4546–53. doi:10.1038/sj.onc.1202843. PMID 10467399.
Schneikert J, Hübner S, Martin E, Cato AC (1999). "A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.". J. Cell Biol. 146 (5): 929–40. doi:10.1083/jcb.146.5.929. PMID 10477749.
Lüders J, Demand J, Höhfeld J (2000). "The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome.". J. Biol. Chem. 275 (7): 4613–7. doi:10.1074/jbc.275.7.4613. PMID 10671488.

This article on a gene on chromosome 9 is a stub. You can help Wikipedia by expanding it.

[pmid7834747-0] Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (Mar 1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell 80 (2): 279–84. PMID 7834747.

[entrez-1] "Entrez Gene: BAG1 BCL2-associated athanogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573.

[2] Physorg:Old Cells Work Differently

[pmid9642262-3] Liu, R; Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K (Jul. 1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. Biol. Chem. (UNITED STATES) 273 (27): 16985–92. ISSN 0021-9258. PMID 9642262.

[pmid8692945-4] Wang, H G; Takayama S, Rapp U R, Reed J C (Jul. 1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (14): 7063–8. ISSN 0027-8424. PMID 8692945.

[pmid12724406-5] Hung, Wesley J; Roberson Rachel S, Taft Jaime, Wu Daniel Y (May. 2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. (United States) 23 (10): 3477–86. ISSN 0270-7306. PMID 12724406.

[pmid14517289-6] Shatkina, Liubov; Mink Sigrun, Rogatsch Hermann, Klocker Helmut, Langer Gernot, Nestl Andrea, Cato Andrew C B (Oct. 2003). "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor". Mol. Cell. Biol. (United States) 23 (20): 7189–97. ISSN 0270-7306. PMID 14517289.

[pmid11278763-7] Knee, D A; Froesch B A, Nuber U, Takayama S, Reed J C (Apr. 2001). "Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity". J. Biol. Chem. (United States) 276 (16): 12718–24. doi:10.1074/jbc.M010841200. ISSN 0021-9258. PMID 11278763.

[pmid9565586-8] Froesch, B A; Takayama S, Reed J C (May. 1998). "BAG-1L protein enhances androgen receptor function". J. Biol. Chem. (UNITED STATES) 273 (19): 11660–6. ISSN 0021-9258. PMID 9565586.

[pmid9305631-9] Takayama, S; Bimston D N, Matsuzawa S, Freeman B C, Aime-Sempe C, Xie Z, Morimoto R I, Reed J C (Aug. 1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70". EMBO J. (ENGLAND) 16 (16): 4887–96. doi:10.1093/emboj/16.16.4887. ISSN 0261-4189. PMID 9305631.

[pmid9873016-10] Takayama, S; Xie Z, Reed J C (Jan. 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J. Biol. Chem. (UNITED STATES) 274 (2): 781–6. ISSN 0021-9258. PMID 9873016.

[pmid11340068-11] Lin, J; Hutchinson L, Gaston S M, Raab G, Freeman M R (Aug. 2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation". J. Biol. Chem. (United States) 276 (32): 30127–32. doi:10.1074/jbc.M010237200. ISSN 0021-9258. PMID 11340068.

[pmid9603979-12] Kullmann, M; Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato A C (Jun. 1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis". J. Biol. Chem. (UNITED STATES) 273 (23): 14620–5. ISSN 0021-9258. PMID 9603979.

[pmid11101523-13] Schneikert, J; Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato A C (Dec. 2000). "Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor". EMBO J. (ENGLAND) 19 (23): 6508–16. doi:10.1093/emboj/19.23.6508. ISSN 0261-4189. PMID 11101523.

[pmid10967105-14] Guzey, M; Takayama S, Reed J C (Dec. 2000). "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. Chem. (UNITED STATES) 275 (52): 40749–56. doi:10.1074/jbc.M004977200. ISSN 0021-9258. PMID 10967105.

[pmid9582267-15] Matsuzawa, S; Takayama S, Froesch B A, Zapata J M, Reed J C (May. 1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1". EMBO J. (ENGLAND) 17 (10): 2736–47. doi:10.1093/emboj/17.10.2736. ISSN 0261-4189. PMID 9582267.

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