Autoimmune polyendocrine syndrome type 2 is a form of autoimmune polyendocrine syndrome.

Autoimmune polyendocrine syndrome, type 2 (also known as "Schmidt's syndrome"^[1], or APS-II) is the most common form of the polyglandular failure syndromes.^[2] It is more heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular HLA genotype (DQ2, DQ8 and DRB1*0404). APS-II affects women to a greater degree than men (75% of cases occur in women).^[2]

Features of this syndrome are:

• Addison's disease^[3]
• hypothyroidism
• diabetes mellitus (type 1)
• less common associations:
  • hypogonadism
  • vitiligo

Symptoms Addison's Disease and Hashimoto's Thyroiditis Type 2

• Dry hair
• Nausea
• Abdominal Pain
• Frequent Urination^{[citation needed]}
• Overheating^{[citation needed]}
• Vomiting
• Weight and Muscle Loss
• Salt Cravings
• Anorexia and chachexia
• High Pulse/Weakened Heart
• Low Blood Pressure
• Weakness
• Hypoglycemia
• Numbness in Extremities
• Migraines
• Poor Immune System Response - Lacking Natural Bodily Inflammatories

Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3^[4] and 4), but research evidence for these distinct combinations is not convincing.

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