Atrioventricular node Information & Atrioventricular node Links at HealthHaven.com

Atrioventricular node
	AV node visible near bend of red line.
	Heart; conduction system
Latin	nodus atrioventricularis
Artery	atrioventricular nodal branch

The atrioventricular node (abbreviated AV node) is a part of electrical control system of the heart that co-ordinates heart rate. It electrically connects atrial and ventricular chambers.^[1] The AV node is an area of specialized tissue between the atria and the ventricles of the heart, specifically in the posteroinferior region of the interatrial septum near the opening of the coronary sinus, which conducts the normal electrical impulse from the atria to the ventricles. The AV node is quite compact (~1 x 3 x 5 mm).^[2] It is located at the center of Koch's Triangle—a triangle enclosed by the septal leaflet of the tricuspid valve, the coronary sinus, and the membraneous part of the interatrial septum.^[3]

The AV node may also be (rarely) referred to as the Aschoff-Tawara node.^[4]

[edit] Function

Contraction of myocytes (heart muscle cells) requires depolarization and repolarization of their cell membranes. Movement of ions across cell membranes causes these events. The cardiac conduction system (and AV node part of it) coordinates myocyte mechanical activity. A wave of excitation spreads out from the sinoatrial node through the atria along specialized conduction channels. This activates the AV node.^[1] The atrioventricular node delays impulses by approximately 0.12s. This delay in the cardiac pulse is extremely important: It ensures that the atria have ejected their blood into the ventricles first before the ventricles contract.^[5] This also protects the ventricles from excessively fast rate response to atrial arrhythmias (see below).^[6]

The AV node receives two inputs from the atria: posteriorly, via the crista terminalis, and anteriorly, via the interatrial septum.^[7]

AV conduction during normal cardiac rhythm occurs through two different pathways:

the first “pathway” has a slow conduction velocity but shorter refractory period
the second “pathway” has a faster conduction velocity but longer refractory period.^[8]

An important property that is unique to the AV node is decremental conduction,^[9] in which the more frequently the node is stimulated the slower it conducts. This is the property of the AV node that prevents rapid conduction to the ventricle in cases of rapid atrial rhythms, such as atrial fibrillation or atrial flutter.

The AV node's normal intrinsic firing rate without stimulation (like from the SA node) is 40-60 times/minute.^[10]

[edit] Blood supply

The blood supply can vary.^[11]

The blood supply of the AV node is from the posterior interventricular artery, which is a branch of the right coronary artery in right-dominant individuals.

In the remainder of individuals, the AV node is still supplied by the posterior interventricular artery, but that artery is a branch of the left circumflex artery; the coronary circulation of these individuals is considered left-dominant.

[edit] Disorders

Atrioventricular (AV) conduction disease (AV block) describes impairment of the electrical continuity between the atria and ventricles. It occurs when the atrial depolarization fail to reach the ventricles or is conducted with a delay. It can result from an injury or be a genetically inherited disorder.^[12]
Atrioventricular nodal re-entry tachycardia^[8]
Cystic tumour of atrioventricular nodal region (CTAVN) CTAVN is of endodermal origin and occurs exclusively in the area of the AV node, tricuspid valve, and interatrial septum.^[13]

[edit] Development

BMP (Bone morphogenetic protein) cell signaling plays a key role in diverse aspects of cardiac differentiation and morphogenesis. (BMPs) are multifunctional signaling molecules critical for the development of AV node. BMP influences AV node development through Alk3 receptor (Activin receptor-like kinase 3). Abnormalities seen in BMP and Alk3 are associated with some cardiovascular diseases like Ebstein’s anomaly and AV conduction disease.^[14]

[edit] See also

Electrical conduction system of the heart
Sinoatrial node (SA node)

[edit] References

^ ^a ^b Gray, Huon H.; Keith D. Dawkins, Iain A. Simpson and John M. Morgan (2002). Lecture Notes on Cardiology. Boston: Blackwell Science. p. 135. ISBN 978-0-86542-864-5.
^ Full Size Picture triangle of-Koch.jpg. Retrieved on 2008-12-22
^ Harrison's Principles of Internal Medicine, 17e” Section 3: Disorders of Rhythm
^ synd/454 at Who Named It?
^ Campbell, N., & Reece, J. (2002). Biology. 6th ed. San Francisco: Benjamin Cummings^{[page needed]}
^ Gray, Huon H.; Keith D. Dawkins, Iain A. Simpson and John M. Morgan (2002). Lecture Notes on Cardiology. Boston: Blackwell Science. p. 136. ISBN 978-0-86542-864-5.
^ Fuster V, Rydén LE, Asinger RW, et al. (October 2001). "ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation". Journal of the American College of Cardiology 38 (4): 1231–66. doi:10.1016/S0735-1097(01)01587-X. PMID 11583910. http://www.americanheart.org/downloadable/heart/222_ja20017993p_1.pdf.
^ ^a ^b Gray, Huon H.; Keith D. Dawkins, Iain A. Simpson and John M. Morgan (2002). Lecture Notes on Cardiology. Boston: Blackwell Science. p. 157. ISBN 978-0-86542-864-5.
^ Patterson E, Scherlag BJ (October 2002). "Decremental conduction in the posterior and anterior AV nodal inputs". Journal of Interventional Cardiac Electrophysiology 7 (2): 137–48. doi:10.1023/A:1020833604423. PMID 12397223.
^ Guyton, Arthur C.; John E. Hall (2006). Textbook of Medical Physiology (11 ed.). Philadelphia: Elsevier Saunders. p. 120. ISBN 0721602401.
^ Van der Hauwaert LG, Stroobandt R, Verhaeghe L (October 1972). "Arterial blood supply of the atrioventricular node and main bundle". British Heart Journal 34 (10): 1045–51. doi:10.1136/hrt.34.10.1045. PMID 5086972.
^ Benson DW (October 2004). "Genetics of atrioventricular conduction disease in humans". The Anatomical Record. Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 280 (2): 934–9. doi:10.1002/ar.a.20099. PMID 15372490.
^ Sharma G, Linden MD, Schultz DS, Inamdar KV (January 2009). "Cystic tumor of the atrioventricular node: an unexpected finding in an explanted heart". Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. doi:10.1016/j.carpath.2008.10.011. PMID 19144541.
^ Stroud DM, Gaussin V, Burch JB, et al. (November 2007). "Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor". Circulation 116 (22): 2535–43. doi:10.1161/CIRCULATIONAHA.107.696583. PMID 17998461.

[edit] External links

SUNY Figs 20:06-02 - "The conduction system of the heart."
thoraxlesson4 at The Anatomy Lesson by Wesley Norman (Georgetown University) (thoraxheartinternalner)
http://www.healthyheart.nhs.uk/heart_works/heart03.shtml

[gray2002p135-0] Gray, Huon H.; Keith D. Dawkins, Iain A. Simpson and John M. Morgan (2002). Lecture Notes on Cardiology. Boston: Blackwell Science. p. 135. ISBN 978-0-86542-864-5.

[1] Full Size Picture triangle of-Koch.jpg. Retrieved on 2008-12-22

[2] Harrison's Principles of Internal Medicine, 17e” Section 3: Disorders of Rhythm

[3] synd/454 at Who Named It?

[4] Campbell, N., & Reece, J. (2002). Biology. 6th ed. San Francisco: Benjamin Cummings^{[page needed]}

[5] Gray, Huon H.; Keith D. Dawkins, Iain A. Simpson and John M. Morgan (2002). Lecture Notes on Cardiology. Boston: Blackwell Science. p. 136. ISBN 978-0-86542-864-5.

[6] Fuster V, Rydén LE, Asinger RW, et al. (October 2001). "ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation". Journal of the American College of Cardiology 38 (4): 1231–66. doi:10.1016/S0735-1097(01)01587-X. PMID 11583910. http://www.americanheart.org/downloadable/heart/222_ja20017993p_1.pdf.

[gray2002p157-7] Gray, Huon H.; Keith D. Dawkins, Iain A. Simpson and John M. Morgan (2002). Lecture Notes on Cardiology. Boston: Blackwell Science. p. 157. ISBN 978-0-86542-864-5.

[8] Patterson E, Scherlag BJ (October 2002). "Decremental conduction in the posterior and anterior AV nodal inputs". Journal of Interventional Cardiac Electrophysiology 7 (2): 137–48. doi:10.1023/A:1020833604423. PMID 12397223.

[9] Guyton, Arthur C.; John E. Hall (2006). Textbook of Medical Physiology (11 ed.). Philadelphia: Elsevier Saunders. p. 120. ISBN 0721602401.

[pmid5086972-10] Van der Hauwaert LG, Stroobandt R, Verhaeghe L (October 1972). "Arterial blood supply of the atrioventricular node and main bundle". British Heart Journal 34 (10): 1045–51. doi:10.1136/hrt.34.10.1045. PMID 5086972.

[11] Benson DW (October 2004). "Genetics of atrioventricular conduction disease in humans". The Anatomical Record. Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 280 (2): 934–9. doi:10.1002/ar.a.20099. PMID 15372490.

[12] Sharma G, Linden MD, Schultz DS, Inamdar KV (January 2009). "Cystic tumor of the atrioventricular node: an unexpected finding in an explanted heart". Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. doi:10.1016/j.carpath.2008.10.011. PMID 19144541.

[13] Stroud DM, Gaussin V, Burch JB, et al. (November 2007). "Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor". Circulation 116 (22): 2535–43. doi:10.1161/CIRCULATIONAHA.107.696583. PMID 17998461.

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