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Arsinoe I (Greek: Ἀρσινόη, 305/295 BC-247 BC) was queen of Egypt 284/1-ca. 274 BC and first wife of Ptolemy II of Egypt.

Arsinoe I was the daughter of Lysimachus, king of Thrace, Asia Minor and Macedon. She bore Ptolemy II's the three children, including his successor Ptolemy III of Egypt. She married Ptolemy II in 284/1 BC. Around 274 BC, she was convicted of plotting against him and went in exile from Egypt to Coptos, and soon Ptolemy II married his sister Arsinoe II of Egypt. Arsinoe died in her exile twenty-seven years later.

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