Phenazone

Systematic (IUPAC) name
1,2-dihydro- 1,5-dimethyl- 2-phenyl- 3H-pyrazol- 3-one
Identifiers
CAS number	60-80-0
ATC code	N02BB01
PubChem	2206
DrugBank	DB01435
ChemSpider	2121
Chemical data
Formula	C11H12N2O
Mol. mass	188.226
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?
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Phenazone, or phenazon, is an analgesic. It was first synthesized by Ludwig Knorr in 1883.^[1] It is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene- ortho- dihydrazine with hydrochloric acid to 150 C. It crystallizes in needles which melt at 156 C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.

[edit] Synonyms

Analgesine, Antipyrine, Diméthyloxyquinazine, Oxydiméthylquinazine, Oxydiméthylquinizine, Pyrazoline

[edit] See also

• Propyphenazone
• A/B Otic Drops- An ear drop combined with benzocaine to relieve pain and remove cerumen.

[edit] Chimic Class

• Pyrazole
• Pyrazolinone

[edit] Pharmacology

• Analgesics
• Antipyretic
• NSAID

[edit] Adverse effects

• Allergy to pyrazolones
• Nausea
• Agranulocytosis
• hepatotoxic

[edit] References