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Andrew Jess Dannenberg (born 17 February 1956) is a U.S. physician and researcher, currently Henry R. Erle, M.D. - Roberts Family Professor of Medicine at Weill Medical College/M.D. Anderson Cancer Center. He additionally holds the positions there of Professor of Medicine in Cardiothoracic Surgery and Director of Cancer Prevention. He received a B.s. from Tufts University in 1978 and a M.D. from Washington University School of Medicine in 1982.
[edit] NSAIDs and cancer controversy
In January 2006, it was revealed that an article (The Lancet, October 2005) he had co-authored with Norwegian researcher Jon Sudbø was a scientific misconduct and retracted.[1] The paper had reported on the side effects of other NSAIDs on oral cancer, saying "Our findings highlight how a commonly used drug can have a benefit from the standpoint of cancer prevention but can also have side effects - in this case, an increased risk for cardiovascular death ..." [2][3][4]
According to the Norwegian daily Verdens Gang, Dannenberg may have been instrumental in the conception of the article ([1], in Norwegian). An independent Commission of Inquiry led by Swedish Professor Anders Ekbom found no evidence that any of his co-authors had taken part in the fraud or otherwise been party to the deceit.[5]
[edit] Honors
- Upjohn Achievement Award for scientific research
- American Liver Foundation Scholar Award and the
- International Life Sciences Research Foundation Award.
[edit] Publications
His current work deals with the role of cyclooxygenase-2 (COX-2) in cancer.[6] ,[7],[8] He has previously been one of the three lead investigators of a major study on the role of aspirin in the prevention of breast cancer.[9].
[edit] Journals
According to Web of Science, he has published over 200 peer-reviewed articles, of which 27 have cited over 100 times. The most cited are:
- "Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis" by Boolbol SK, Dannenberg AJ, Chadburn A, in Cancer Research 56(11)2556-2560 (1996) Times Cited: 401
- "Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer" by Tucker ON, Dannenberg AJ, Yang FK, et al. in Cancer Research 59 (5) 987-990 (1999)Times Cited: 386
- "Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck" by Chan G, Boyle JO, Yang EK, et al. in Cancer Research 59 (5) 991-994 (1999) Times Cited: 384
- "COX‐2 is expressed in human pulmonary, colonic, and mammary tumors" RA Soslow, AJ Dannenberg, D Rush, BM Woerner, KN. in Cancer: 89 ( 12) 2637-2645 (2000) Times Cited: 289
[edit] Editor
- COX-2: A New Target for Cancer Prevention and Treatment ed. by R. N. Dubois and A. J. Dannenberg Basel ; New York : Karger, 2003. ISBN 380557536X 978380557536
- The role of COX-2 carcinogenesis by Andrew J Dannenberg; Raymond N Dubois; Steven M Dubinett; Nasser K Altorki; et al. Philadelphia, PA : Saunders, 2004. OCLC: 66570293
- Peptic ulcer disease and other acid-related disorders by David Zakim; Andrew J Dannenberg Armonk, N.Y. : Academic Research Associates, 1991. ISBN 9780962918001
[edit] References
- ^ Horton, Richard (4 February 2006). "Retraction — Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study". The Lancet.
- ^ "Use Of Non-COX-2-specific NSAIDs Halves Odds For Oral Cancer: Doubles Cardiovascular Death Risk". Science Daily. October 7, 2005. http://www.sciencedaily.com/releases/2005/10/051007083413.htm. Retrieved 2008-03-26. "An analysis of 20 years of data on the health of over 900 adults has found that long-term use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, cuts the risk for oral cancer in smokers by half."
- ^ Dannenberg, Andrew (October 15, 2005). "Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study". The Lancet. http://www.ncbi.nlm.nih.gov/pubmed/16226613. Retrieved 2008-03-26. "Non-steroidal anti-inflammatory drugs (NSAIDs) seem to prevent several types of cancer, but could increase the risk of cardiovascular complications. We investigated whether use of NSAIDs was associated with a change in the incidence of oral cancer or overall or cardiovascular mortality."
- ^ "Fraud charges against Norwegian researcher stoke confusion over painkillers". Associated Press. January 17, 2006. "Fraud accusations against a Norwegian researcher have muddied the question of whether popular over-the-counter pain relievers fight cancer or harm the heart. Norway's Comprehensive Cancer Center said over the weekend that one of its researchers admitted fabricating data used in a study that said common pain relievers, including ibuprofen (sold as Motrin and Advil) and naproxen (Naprosyn, Aleve), lowered the risk of oral cancer but heightened the risk of heart problems...."
- ^ Kihlström, Staffan (2006-05-06). "60 forskare granskas efter fuskskandal" (in Swedish). Dagens Nyheter. http://www.dn.se/DNet/jsp/polopoly.jsp?d=597&a=542859.
- ^ " COX-2 Inhibitors for Cancer Prevention & Treatment: Research Roundup: " by Lindsey, Heather Oncology Times
- ^ " COX-2 Inhibitors: Cancer Trials Test New Uses for Pain Drug" by Jennifer Michalowski Journal of the National Cancer Institute 24(4)April 2002p 52-54
- ^ "Researchers Plan To Continue To Study COX-2 Inhibitors in Cancer Treatment and Prevention" by Cori Vanchieri. JNCI Spectrum (with portrait)
- ^ "Women who regularly take aspirin at lower risk of breast cancer" Women's Health News Monday, 31-May-2004
[edit] External links
