Ambenonium chloride Information & Ambenonium chloride Links at HealthHaven.com

Ambenonium chloride
Systematic (IUPAC) name
	2,2'-[(1,2-dioxoethane-1,2-diyl)diimino]bis[N-(2-chlorobenzyl)-N,N-diethylethanaminium]
Identifiers
CAS number	7648-98-8
ATC code	N07AA30
PubChem	8288
DrugBank	APRD00771
ChemSpider	7987
Chemical data
Formula	C28H42Cl2N4O2+2
Mol. mass	537.564 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	Low
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral
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Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor^[1] used in the management of myasthenia gravis.

It is classified as reversible.^[2]

[edit] Mechanism of Action

Ambenonium exerts its actions against Myasthenia Gravis by competitive reversible inhibition of acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine. Myasthenia Gravis occurs when the body produces antibodies against acetylcholine receptors, and thus inhibits signal transmission across the myoneural junction. Ambenonium reversibly binds acetylcholinesterase, inactivates it and therefore increases levels of acetylcholine. This, in turn, facilitates transmission of impulses across the myoneural junction and effectively treats the disease

[edit] Indications

Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).

[edit] References

^ Bolognesi ML, Cavalli A, Andrisano V, et al. (September 2003). "Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors". Farmaco 58 (9): 917–28. doi:10.1016/S0014-827X(03)00150-2. PMID 13679187. http://linkinghub.elsevier.com/retrieve/pii/S0014827X03001502.
^ Hodge AS, Humphrey DR, Rosenberry TL (May 1992). "Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities". Mol. Pharmacol. 41 (5): 937–42. PMID 1588924. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=1588924.

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[pmid13679187-0] Bolognesi ML, Cavalli A, Andrisano V, et al. (September 2003). "Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors". Farmaco 58 (9): 917–28. doi:10.1016/S0014-827X(03)00150-2. PMID 13679187. http://linkinghub.elsevier.com/retrieve/pii/S0014827X03001502.

[pmid1588924-1] Hodge AS, Humphrey DR, Rosenberry TL (May 1992). "Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities". Mol. Pharmacol. 41 (5): 937–42. PMID 1588924. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=1588924.

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