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Adult-onset Still's disease
	Classification and external resources
ICD-10	M06.1
ICD-9	714.2
DiseasesDB	34295
MedlinePlus	000450
MeSH	D016706

Adult-onset Still's disease is a form of rheumatoid arthritis that was characterized by Bywaters in 1971.^[1]

The "Still" is for English physician Sir George Frederic Still (1861-1941). ^[2]^[3]

The condition "juvenile-onset Still disease" is now usually grouped under juvenile rheumatoid arthritis. However, there is some evidence that the two conditions are closely related.^[4]

The diagnosis is clinical, not based upon serology.^[5]

The disease typically affects 16-35 year olds and presents with arthralgia, elevated serum ferritin, a 'salmon-pink' rash, pyrexia and lymphadenopathy. Rheumatoid factor (RF) and anti-nuclear antibody (ANA) are classically negative. Patients experiencing a flare-up from Adult Onset Still's Disease usually report extreme fatigue, swelling of the lymph glands, and less commonly fluid accumulation in the lungs and heart.

A common 'differential diagnosis' for Still's is Lyme disease.

Treatment for Adult-Onset Still's disease is with anti-inflammatory drugs. Cortisone medications (steroids) such as prednisone are used to treat severe symptoms of Still's. Other medications include Plaquenil, Cuprimine, Imuran, Methotrexate, Enbrel, Kineret, Cytoxin, Humira, Rituxan, and Remicade.

[edit] References

^ Bywaters EG (March 1971). "Still's disease in the adult". Ann. Rheum. Dis. 30 (2): 121–33. PMID 5315135. PMC 1005739. http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=5315135.
^ synd/1773 at Who Named It?
^ G. F. Still. A special form of joint disease met with in children. Doctoral dissertation, Cambridge, 1896.
^ Luthi F, Zufferey P, Hofer MF, So AK (2002). ""Adolescent-onset Still's disease": characteristics and outcome in comparison with adult-onset Still's disease". Clin. Exp. Rheumatol. 20 (3): 427–30. PMID 12102485.
^ Efthimiou P, Kontzias A, Ward CM, Ogden NS (June 2007). "Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy?". Nat Clin Pract Rheumatol 3 (6): 328–35. doi:10.1038/ncprheum0510. PMID 17538564. http://dx.doi.org/10.1038/ncprheum0510.

[pmid5315135-0] Bywaters EG (March 1971). "Still's disease in the adult". Ann. Rheum. Dis. 30 (2): 121–33. PMID 5315135. PMC 1005739. http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=5315135.

[1] synd/1773 at Who Named It?

[2] G. F. Still. A special form of joint disease met with in children. Doctoral dissertation, Cambridge, 1896.

[pmid12102485-3] Luthi F, Zufferey P, Hofer MF, So AK (2002). ""Adolescent-onset Still's disease": characteristics and outcome in comparison with adult-onset Still's disease". Clin. Exp. Rheumatol. 20 (3): 427–30. PMID 12102485.

[pmid17538564-4] Efthimiou P, Kontzias A, Ward CM, Ogden NS (June 2007). "Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy?". Nat Clin Pract Rheumatol 3 (6): 328–35. doi:10.1038/ncprheum0510. PMID 17538564. http://dx.doi.org/10.1038/ncprheum0510.

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