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Adult-onset Still's disease
	Classification and external resources
ICD-10	M06.1
ICD-9	714.2
DiseasesDB	34295
MedlinePlus	000450
MeSH	D016706

Adult-onset Still's disease is a form of rheumatoid arthritis that was characterized by Bywaters in 1971.^[1]

The "Still" is for English physician Sir George Frederic Still (1861-1941). ^[2]^[3]

The condition "juvenile-onset Still disease" is now usually grouped under juvenile rheumatoid arthritis. However, there is some evidence that the two conditions are closely related.^[4]

The diagnosis is clinical, not based upon serology.^[5]

The disease typically affects 16-35 year olds and presents with arthralgia, elevated serum ferritin, a 'salmon-pink' rash, pyrexia and lymphadenopathy. Rheumatoid factor (RF) and anti-nuclear antibody (ANA) are classically negative. Patients experiencing a flare-up from Adult Onset Still's Disease usually report extreme fatigue, swelling of the lymph glands, and less commonly fluid accumulation in the lungs and heart.

A common 'differential diagnosis' for Still's is Lyme disease.

Treatment for Adult-Onset Still's disease is with anti-inflammatory drugs. Cortisone medications (steroids) such as prednisone are used to treat severe symptoms of Still's. Other medications include Plaquenil, Cuprimine, Imuran, Methotrexate, Enbrel, Kineret, Cytoxin, Humira, Rituxan, and Remicade.

Adult-Onset Still's Disease is chronic; and reports of remission is either slim or temporary at best.

[edit] References

^ Bywaters EG (March 1971). "Still's disease in the adult". Ann. Rheum. Dis. 30 (2): 121–33. PMID 5315135. PMC 1005739. http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=5315135.
^ synd/1773 at Who Named It?
^ G. F. Still. A special form of joint disease met with in children. Doctoral dissertation, Cambridge, 1896.
^ Luthi F, Zufferey P, Hofer MF, So AK (2002). ""Adolescent-onset Still's disease": characteristics and outcome in comparison with adult-onset Still's disease". Clin. Exp. Rheumatol. 20 (3): 427–30. PMID 12102485.
^ Efthimiou P, Kontzias A, Ward CM, Ogden NS (June 2007). "Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy?". Nat Clin Pract Rheumatol 3 (6): 328–35. doi:10.1038/ncprheum0510. PMID 17538564. http://dx.doi.org/10.1038/ncprheum0510.

[pmid5315135-0] Bywaters EG (March 1971). "Still's disease in the adult". Ann. Rheum. Dis. 30 (2): 121–33. PMID 5315135. PMC 1005739. http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=5315135.

[1] synd/1773 at Who Named It?

[2] G. F. Still. A special form of joint disease met with in children. Doctoral dissertation, Cambridge, 1896.

[pmid12102485-3] Luthi F, Zufferey P, Hofer MF, So AK (2002). ""Adolescent-onset Still's disease": characteristics and outcome in comparison with adult-onset Still's disease". Clin. Exp. Rheumatol. 20 (3): 427–30. PMID 12102485.

[pmid17538564-4] Efthimiou P, Kontzias A, Ward CM, Ogden NS (June 2007). "Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy?". Nat Clin Pract Rheumatol 3 (6): 328–35. doi:10.1038/ncprheum0510. PMID 17538564. http://dx.doi.org/10.1038/ncprheum0510.

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