Aceclidine

Systematic (IUPAC) name
1-azabicyclo [2.2.2]oct- 3-yl acetate
Identifiers
CAS number	827-61-2 6109-70-2 (HCl)
ATC code	S01EB08
PubChem	1979
ChemSpider	1902
Chemical data
Formula	C9H15NO2
Mol. mass	169.221 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Ocular
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Aceclidine (INN) (trade names Glaucostat, Glaunorm, Glaudin) is a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma. It decreases intraocular pressure.

[edit] Adverse effects

Side effects of aceclidine include increased salivation, bradycardia (in excessive doses).

[edit] Mechanism of action

Aceclidine acts primarily on the muscarinic receptor.^[1]

[edit] References

• ACECLIDINE CHLORHYDRATE [Article in French] Biam. Last update: 2 September 1999. Accessed 13 September 2005 (UTC)
• ACECLIDINE (АЦЕКЛИДИН) [Article in Russian] ViDAL 2005. Accessed 13 September 2005.

v • d • e Parasympathomimetics / cholinergic agonists / acetylcholinesterase inhibitors (N06DA, N07AA) Direct (at receptor) muscarinic: Muscarine  · Oxotremorine  · M1 (Vedaclidine • Xanomeline)  · M3 (Bethanechol, Pilocarpine, Arecoline, Cevimeline, Aceclidine, Alvameline)  · Methacholine nicotinic: Nicotine (low doses) · Lobeline · Varenicline · Epibatidine  · Dimethylphenylpiperazinium M & N: Acetylcholine/Choline alfoscerate · Carbachol Indirect/AIs (in synapse) Reversible very short acting: Edrophonium carbamates/stigmine: Ambenonium · Rivastigmine · Distigmine · tertiary/CNS (Physostigmine) · quaternary/peripheral (Neostigmine, Pyridostigmine) anti-dementia (Galantamine, Donepezil, Tacrine, Ladostigil) Irreversible/ organophosphate ophthalmological (Ecothiopate, Isoflurophate, Demecarium) antiparasitic (Malathion, Metrifonate) chemical warfare (see Nerve agent)

v • d • e Ophthalmologicals: antiglaucoma preparations and miotics (S01E) Sympathomimetics Apraclonidine • Brimonidine • Clonidine • Dipivefrine • Epinephrine Parasympathomimetics muscarinic Aceclidine • Pilocarpine muscarinic/nicotinic Acetylcholine • Carbachol Acetylcholinesterase inhibitors Demecarium • Ecothiopate • Stigmine (Fluostigmine, Neostigmine, Physostigmine) • Paraoxon Carbonic anhydrase inhibitors/ (sulfonamides) Acetazolamide • Brinzolamide • Diclofenamide • Dorzolamide • Methazolamide Beta blocking agents Befunolol • Betaxolol • Carteolol • Levobunolol • Metipranolol • Timolol Prostaglandin analogues (F2α) Bimatoprost • Latanoprost • Tafluprost • Travoprost • Unoprostone Other agents Dapiprazole • Guanethidine

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