AP4B1 Information & AP4B1 Links at HealthHaven.com

Adaptor-related protein complex 4, beta 1 subunit
Identifiers
Symbols	AP4B1; BETA-4
External IDs	OMIM: 607245 MGI: 1337130 HomoloGene: 38203
Gene ontology
Molecular function	• transporter activity; • binding;
Cellular component	• soluble fraction; • trans-Golgi network; • coated pit;
Biological process	• protein transport;
Orthologs
NP_006585 (protein)	NP_080469 (protein)

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AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.^[1]^[2]

The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4 (AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM 607243).[supplied by OMIM]^[2]

[edit] Interactions

AP4B1 has been shown to interact with AP4M1.^[3]

[edit] References

^ Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors". J Biol Chem 274 (11): 7278-85. PMID 10066790.
^ ^a ^b "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10717.
^ Hirst, J; Bright N A, Rous B, Robinson M S (Aug. 1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell (UNITED STATES) 10 (8): 2787-802. ISSN 1059-1524. PMID 10436028.

[edit] Further reading

Hirst J, Bright NA, Rous B, Robinson MS (1999). "Characterization of a fourth adaptor-related protein complex.". Mol. Biol. Cell 10 (8): 2787–802. PMID 10436028.
Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
Cayrol C, Cougoule C, Wright M (2003). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1.". Biochem. Biophys. Res. Commun. 298 (5): 720–30. doi:10.1016/S0006-291X(02)02522-6. PMID 12419313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.

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[pmid10066790-0] Dell'Angelica EC, Mullins C, Bonifacino JS (Apr 1999). "AP-4, a novel protein complex related to clathrin adaptors". J Biol Chem 274 (11): 7278-85. PMID 10066790.

[entrez-1] "Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10717.

[pmid10436028-2] Hirst, J; Bright N A, Rous B, Robinson M S (Aug. 1999). "Characterization of a fourth adaptor-related protein complex". Mol. Biol. Cell (UNITED STATES) 10 (8): 2787-802. ISSN 1059-1524. PMID 10436028.

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