ANGPTL3 Information & ANGPTL3 Links at HealthHaven.com

Angiopoietin-like 3
Identifiers
Symbols	ANGPTL3; ANGPT5
External IDs	OMIM: 604774 MGI: 1353627 HomoloGene: 8499 GeneCards: ANGPTL3 Gene
Gene ontology
Molecular function	• enzyme inhibitor activity; • integrin binding;
Cellular component	• extracellular region;
Biological process	• triacylglycerol metabolic process; • cell-matrix adhesion; • signal transduction; • integrin-mediated signaling pathway; • lipid catabolic process; • positive regulation of cell migration; • positive regulation of angiogenesis; • positive regulation of lipid metabolic process;
RNA expression pattern
	More reference expression data
Orthologs

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Angiopoietin-like 3, also known as ANGPTL3, is a protein which in humans is encoded by the ANGPTL3 gene.^[1]^[2]

[edit] Function

The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.^[1] Angptl3 also acts as dual inhibitor of LPL and EL, and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities. In human, ANGPTL3 is a determinant factor of HDL level and positively correlates with plasma HDL cholesterol.

[edit] References

^ ^a ^b "Entrez Gene: ANGPTL3 angiopoietin-like 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27329.
^ Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, Walker KM, Chen LH, Wattler S, Nehls M, Lewis KB (December 1999). "Identification of a mammalian angiopoietin-related protein expressed specifically in liver". Genomics 62 (3): 477–82. doi:10.1006/geno.1999.6041. PMID 10644446.

[edit] Further reading

Miida T, Seino U, Miyazaki O, Hanyu O, Hirayama S, Saito T, Ishikawa Y, Akamatsu S, Nakano T, Nakajima K, Okazaki M, Okada M (October 2008). "Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alpha-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling". Atherosclerosis 200 (2): 329–35. doi:10.1016/j.atherosclerosis.2007.12.031. PMID 18279878.
Moon HD, Nakajima K, Kamiyama K, Takanashi K, Sakurabayashi I, Nagamine T (December 2008). "Higher frequency of abnormal serum angiopoietin-like protein 3 than abnormal cholesteryl ester transfer protein in Japanese hyperalphalipoproteinemic subjects". Clin. Chim. Acta 398 (1-2): 99–104. doi:10.1016/j.cca.2008.08.021. PMID 18804459.
Li C (2007). "Genetics and regulation of angiopoietin-like proteins 3 and 4.". Curr. Opin. Lipidol. 17 (2): 152–6. doi:10.1097/01.mol.0000217896.67444.05. PMID 16531751.
Conklin D, Gilbertson D, Taft DW, et al. (2000). "Identification of a mammalian angiopoietin-related protein expressed specifically in liver.". Genomics 62 (3): 477–82. doi:10.1006/geno.1999.6041. PMID 10644446.
Camenisch G, Pisabarro MT, Sherman D, et al. (2002). "ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.". J. Biol. Chem. 277 (19): 17281–90. doi:10.1074/jbc.M109768200. PMID 11877390.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kaplan R, Zhang T, Hernandez M, et al. (2003). "Regulation of the angiopoietin-like protein 3 gene by LXR.". J. Lipid Res. 44 (1): 136–43. doi:10.1194/jlr.M200367-JLR200. PMID 12518032.
Shimamura M, Matsuda M, Kobayashi S, et al. (2003). "Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes.". Biochem. Biophys. Res. Commun. 301 (2): 604–9. doi:10.1016/S0006-291X(02)03058-9. PMID 12565906.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart.". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
Ono M, Shimizugawa T, Shimamura M, et al. (2004). "Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.". J. Biol. Chem. 278 (43): 41804–9. doi:10.1074/jbc.M302861200. PMID 12909640.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Shimamura M, Matsuda M, Yasumo H, et al. (2007). "Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase.". Arterioscler. Thromb. Vasc. Biol. 27 (2): 366–72. doi:10.1161/01.ATV.0000252827.51626.89. PMID 17110602.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[entrez-0] "Entrez Gene: ANGPTL3 angiopoietin-like 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27329.

[pmid10644446-1] Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, Walker KM, Chen LH, Wattler S, Nehls M, Lewis KB (December 1999). "Identification of a mammalian angiopoietin-related protein expressed specifically in liver". Genomics 62 (3): 477–82. doi:10.1006/geno.1999.6041. PMID 10644446.

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