ANGPTL1 Information & ANGPTL1 Links at HealthHaven.com

Angiopoietin-like 1
Identifiers
Symbols	ANGPTL1; ANG3; ARP1; ANGPT3; AngY; KIAA0351; UNQ162; dJ595C2.2
External IDs	OMIM: 603874 MGI: 1919963 HomoloGene: 83224
Gene ontology
Molecular function	• receptor binding;
Cellular component	• extracellular space;
Biological process	• signal transduction; • transmembrane receptor protein tyrosine kinase signaling pathway;
Orthologs
NP_004664 (protein)	NP_082609 (protein)

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Angiopoietin-related protein 1 is a protein that in humans is encoded by the ANGPTL1 gene.^[1]^[2]^[3]

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.^[3]

[edit] References

^ Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett 443 (3): 353-6. PMID 10025962.
^ Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics 44 (1): 94-100. PMID 9286704.
^ ^a ^b "Entrez Gene: ANGPTL1 angiopoietin-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9068.

[edit] Further reading

Dhanabal M, Jeffers M, LaRochelle WJ, Lichenstein HS (2005). "Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties.". Biochem. Biophys. Res. Commun. 333 (2): 308–15. doi:10.1016/j.bbrc.2005.05.134. PMID 15950186.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMID 10051567.
Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMID 10318855.
Kim I, Moon SO, Koh KN, et al. (1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting.". J. Biol. Chem. 274 (37): 26523–8. doi:10.1074/jbc.274.37.26523. PMID 10473614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart.". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4.". Faseb J. 18 (11): 1200–8. doi:10.1096/fj.03-1466com. PMID 15284220.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.". Cancer Cell 6 (5): 507–16. doi:10.1016/j.ccr.2004.09.030. PMID 15542434.
Smagur A, Szary J, Szala S (2006). "Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours.". Acta Biochim. Pol. 52 (4): 875–9. PMID 15940350.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid10025962-0] Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett 443 (3): 353-6. PMID 10025962.

[pmid9286704-1] Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics 44 (1): 94-100. PMID 9286704.

[entrez-2] "Entrez Gene: ANGPTL1 angiopoietin-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9068.

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