AK2 Information & AK2 Links at HealthHaven.com

Adenylate kinase 2
	; PDB rendering based on 1ak2.
Available structures
	1ak2, 2ak2, 2c9y
Identifiers
Symbols	AK2; ADK2
External IDs	OMIM: 103020 MGI: 87978 HomoloGene: 1227 GeneCards: AK2 Gene
Gene ontology
Molecular function	• nucleotide binding; • adenylate kinase activity; • ATP binding; • kinase activity; • transferase activity; • nucleoside kinase activity;
Cellular component	• mitochondrion; • mitochondrial inner membrane;
Biological process	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;
RNA expression pattern
	More reference expression data
Orthologs

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Adenylate kinase 2, mitochondrial is an enzyme that in humans is encoded by the AK2 gene.^[1]^[2]^[3]

Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Two transcript variants encoding distinct isoforms have been identified for this gene.^[3]

[edit] References

^ Lee Y, Kim JW, Lee IA, Kang HB, Choe YK, Lee HG, Lim JS, Kim HJ, Park C, Choe IS (Feb 1997). "Cloning and characterization of cDNA for human adenylate kinase 2A". Biochem Mol Biol Int 39 (4): 833-42. PMID 8843353.
^ Carritt B, King J, Welch HM (Mar 1983). "Gene order and localization of enzyme loci on the short arm of chromosome 1". Ann Hum Genet 46 (Pt 4): 329-35. PMID 6961883.
^ ^a ^b "Entrez Gene: AK2 adenylate kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=204.

[edit] Further reading

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Köhler C, Gahm A, Noma T, et al. (1999). "Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis.". FEBS Lett. 447 (1): 10–2. doi:10.1016/S0014-5793(99)00251-3. PMID 10218571.
Lee Y, Kim JW, Lee SM, et al. (1998). "Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues.". J. Biochem. 123 (1): 47–54. PMID 9504408.
Noma T, Song S, Yoon YS, et al. (1998). "cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2.". Biochim. Biophys. Acta 1395 (1): 34–9. PMID 9434148.
Hamada M, Sumida M, Okuda H, et al. (1982). "Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne dystrophic serum aberrant adenylate kinase.". J. Biol. Chem. 257 (21): 13120–8. PMID 6182143.
Bruns GA, Regina VM (1977). "Adenylate kinase 2, a mitochondrial enzyme.". Biochem. Genet. 15 (5-6): 477–86. doi:10.1007/BF00520192. PMID 195572.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid8843353-0] Lee Y, Kim JW, Lee IA, Kang HB, Choe YK, Lee HG, Lim JS, Kim HJ, Park C, Choe IS (Feb 1997). "Cloning and characterization of cDNA for human adenylate kinase 2A". Biochem Mol Biol Int 39 (4): 833-42. PMID 8843353.

[pmid6961883-1] Carritt B, King J, Welch HM (Mar 1983). "Gene order and localization of enzyme loci on the short arm of chromosome 1". Ann Hum Genet 46 (Pt 4): 329-35. PMID 6961883.

[entrez-2] "Entrez Gene: AK2 adenylate kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=204.

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