AIM2 Information & AIM2 Links at HealthHaven.com

Absent in melanoma 2
Identifiers
Symbols	AIM2; PYHIN4
External IDs	OMIM: 604578 MGI: 2686159 HomoloGene: 83226 GeneCards: AIM2 Gene
Gene ontology
Biological process	• immune response;
RNA expression pattern
	More reference expression data
Orthologs

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Interferon-inducible protein AIM2 is a protein that in humans is encoded by the AIM2 gene.^[1]^[2]

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.^[2]

[edit] References

^ DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, Trapani JA, Meltzer PS, Trent JM (Aug 1997). "Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma". Oncogene 15 (4): 453-7. doi:10.1038/sj.onc.1201206. PMID 9242382.
^ ^a ^b "Entrez Gene: AIM2 absent in melanoma 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9447.

[edit] Further reading

Landolfo S, Gariglio M, Gribaudo G, Lembo D (1999). "The Ifi 200 genes: an emerging family of IFN-inducible genes.". Biochimie 80 (8-9): 721–8. PMID 9865494.
Woerner SM, Kloor M, Schwitalle Y, et al. (2007). "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.". Genes Chromosomes Cancer 46 (12): 1080–9. doi:10.1002/gcc.20493. PMID 17726700.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Chen IF, Ou-Yang F, Hung JY, et al. (2006). "AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model.". Mol. Cancer Ther. 5 (1): 1–7. doi:10.1158/1535-7163.MCT-05-0310. PMID 16432157.
Cresswell KS, Clarke CJ, Jackson JT, et al. (2005). "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2.". Biochem. Biophys. Res. Commun. 326 (2): 417–24. doi:10.1016/j.bbrc.2004.11.048. PMID 15582594.
Liu G, Yu JS, Zeng G, et al. (2004). "AIM-2: a novel tumor antigen is expressed and presented by human glioma cells.". J. Immunother. 27 (3): 220–6. PMID 15076139.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Choubey D, Walter S, Geng Y, Xin H (2000). "Cytoplasmic localization of the interferon-inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200-gene family.". FEBS Lett. 474 (1): 38–42. PMID 10828447.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid9242382-0] DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, Trapani JA, Meltzer PS, Trent JM (Aug 1997). "Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma". Oncogene 15 (4): 453-7. doi:10.1038/sj.onc.1201206. PMID 9242382.

[entrez-1] "Entrez Gene: AIM2 absent in melanoma 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9447.

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