AHCYL1 Information & AHCYL1 Links at HealthHaven.com

S-adenosylhomocysteine hydrolase-like 1
Identifiers
Symbols	AHCYL1; DCAL; IRBIT; PRO0233; XPVKONA
External IDs	OMIM: 607826 MGI: 2385184 HomoloGene: 77353 GeneCards: AHCYL1 Gene
Gene ontology
Molecular function	• adenosylhomocysteinase activity; • hydrolase activity;
Cellular component	• endoplasmic reticulum;
Biological process	• one-carbon compound metabolic process;
RNA expression pattern
	More reference expression data
Orthologs

edit

Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene.^[1]^[2]^[3]^[4]

[edit] Interactions

AHCYL1 has been shown to interact with ITPR1.^[3]

[edit] References

^ Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID 11904675.
^ Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem 281 (32): 22471–84. doi:10.1074/jbc.M602520200. PMID 16754674.
^ ^a ^b Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.
^ "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10768.

[edit] Further reading

Pawlak A, Toussaint C, Lévy I, et al. (1995). "Characterization of a large population of mRNAs from human testis.". Genomics 26 (1): 151–8. doi:10.1016/0888-7543(95)80096-5. PMID 7782076.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Cleaver JE, Afzal V, Feeney L, et al. (1999). "Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant.". Cancer Res. 59 (5): 1102–8. PMID 10070969.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Shirakabe K, Priori G, Yamada H, et al. (2006). "IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1).". Proc. Natl. Acad. Sci. U.S.A. 103 (25): 9542–7. doi:10.1073/pnas.0602250103. PMID 16769890.

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[pmid11904675-0] Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID 11904675.

[pmid16754674-1] Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem 281 (32): 22471–84. doi:10.1074/jbc.M602520200. PMID 16754674.

[pmid12525476-2] Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.

[entrez-3] "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10768.

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