adenylate cyclase 10 (soluble)
Identifiers
Symbol	ADCY10
Entrez	55811
HUGO	21285
OMIM	605205
RefSeq	NM_018417
UniProt	Q96PN6
Other data
Locus	Chr. 1 q24

Adenylate cyclase 10 also known as ADCY10 is an enzyme which in humans is encoded by the ADCY10 gene.^[1]

[edit] Function

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.^[2]

[edit] Clinical significance

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria.^[1]

[edit] References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This enzyme-related article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Phosphorus-oxygen lyases (EC 4.6) 4.6.1 Adenylate cyclase intracellular: ADCY1 · ADCY2 · ADCY3 · ADCY4 · ADCY5 · ADCY6 · ADCY7 · ADCY8 · ADCY9 · ADCY10 Extracellular adenylate cyclase Guanylate cyclase soluble: GUCY1A2 · GUCY1A3 · GUCY1B2 · GUCY1B3 membrane-bound: Guanylyl cyclase c/GUCY2C · GUCY2D Other Cytidylate cyclase · 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase · Phosphatidylinositol diacylglycerol-lyase · Glycosylphosphatidylinositol diacylglycerol-lyase · FAD-AMP lyase (cyclizing)