ADAM8 Information & ADAM8 Links at HealthHaven.com

ADAM metallopeptidase domain 8
Identifiers
Symbols	ADAM8; CD156; MGC134985; MS2
External IDs	OMIM: 602267 MGI: 107825 HomoloGene: 74384 GeneCards: ADAM8 Gene
Gene ontology
Molecular function	• metalloendopeptidase activity; • zinc ion binding; • metal ion binding;
Cellular component	• plasma membrane; • integral to plasma membrane;
Biological process	• proteolysis; • cell-cell adhesion;
RNA expression pattern
	More reference expression data
Orthologs

edit

Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.^[1]^[2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.^[2]

[edit] See also

Cluster of differentiation

[edit] References

^ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (May 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics 41 (1): 56-62. doi:10.1006/geno.1997.4607. PMID 9126482.
^ ^a ^b "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=101.

[edit] Further reading

Yamamoto S, Higuchi Y, Yoshiyama K, et al. (1999). "ADAM family proteins in the immune system.". Immunol. Today 20 (6): 278–84. doi:10.1016/S0167-5699(99)01464-4. PMID 10354553.
Schlomann U, Rathke-Hartlieb S, Yamamoto S, et al. (2001). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration.". J. Neurosci. 20 (21): 7964–71. PMID 11050116.
Amour A, Knight CG, English WR, et al. (2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.". FEBS Lett. 524 (1-3): 154–8. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ishikawa N, Daigo Y, Yasui W, et al. (2005). "ADAM8 as a novel serological and histochemical marker for lung cancer.". Clin. Cancer Res. 10 (24): 8363–70. doi:10.1158/1078-0432.CCR-04-1436. PMID 15623614.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Foley SC, Mogas AK, Olivenstein R, et al. (2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma.". J. Allergy Clin. Immunol. 119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID 17339047.
Gómez-Gaviro M, Domínguez-Luis M, Canchado J, et al. (2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding.". J. Immunol. 178 (12): 8053–63. PMID 17548643.
Valkovskaya N, Kayed H, Felix K, et al. (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer.". J. Cell. Mol. Med. 11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMID 17979891.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[pmid9126482-0] Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (May 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics 41 (1): 56-62. doi:10.1006/geno.1997.4607. PMID 9126482.

[entrez-1] "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=101.

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[2]