ADAM11 Information & ADAM11 Links at HealthHaven.com

ADAM metallopeptidase domain 11
Identifiers
Symbols	ADAM11; MDC
External IDs	OMIM: 155120 MGI: 1098667 HomoloGene: 7614
Gene ontology
Molecular function	• metalloendopeptidase activity; • integrin binding;
Cellular component	• plasma membrane; • integral to membrane;
Biological process	• proteolysis; • integrin-mediated signaling pathway;
RNA expression pattern
	More reference expression data
Orthologs
NP_002381 (protein)	NP_033743 (protein)

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Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.^[1]^[2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.^[2]

[edit] References

^ Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet 5 (2): 151-7. doi:10.1038/ng1093-151. PMID 8252040.
^ ^a ^b "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4185.

[edit] Further reading

Wolfsberg TG, Primakoff P, Myles DG, White JM (1995). "ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.". J. Cell Biol. 131 (2): 275–8. doi:10.1083/jcb.131.2.275. PMID 7593158.
Katagiri T, Harada Y, Emi M, Nakamura Y (1994). "Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing.". Cytogenet. Cell Genet. 68 (1-2): 39–44. doi:10.1159/000133884. PMID 7956356.
Sagane K, Ohya Y, Hasegawa Y, Tanaka I (1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.". Biochem. J. 334 ( Pt 1): 93–8. PMID 9693107.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid8252040-0] Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet 5 (2): 151-7. doi:10.1038/ng1093-151. PMID 8252040.

[entrez-1] "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4185.

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