ACVR1C Information & ACVR1C Links at HealthHaven.com

activin A receptor
Identifiers
Symbols	ACVR1C; ALK7; ACVRLK7
External IDs	OMIM: 608981 MGI: 2661081 HomoloGene: 26724
Gene ontology
Molecular function	• magnesium ion binding; • activin binding; • ATP binding; • receptor activity; • transforming growth factor beta receptor activity; • activin receptor activity, type I; • protein tyrosine kinase activity; • protein serine/threonine kinase activity; • nucleotide binding; • protein kinase activity; • receptor signaling protein serine/threonine kinase activity; • transferase activity; • transmembrane receptor protein serine/threonine kinase activity; • manganese ion binding;
Cellular component	• membrane; • integral to membrane; • activin receptor complex;
Biological process	• cell differentiation; • response to insulin stimulus; • protein amino acid phosphorylation; • response to dietary excess; • transmembrane receptor protein serine/threonine kinase signaling pathway; • lipid storage; • negative regulation of insulin secretion; • response to glucose stimulus; • regulation of apoptosis;
Orthologs
NP_660302 (protein)	NP_001028541 (protein)

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The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.^[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.^[1]

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a comlex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.^[2]

[edit] References

^ ^a ^b Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3-4): 157–62. PMID 12063393.
^ Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. PMID 12065756.

[edit] Further reading

Carlsson LM, Jacobson P, Walley A, et al. (2009). "ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.". Biochem. Biophys. Res. Commun. 382 (2): 309-14. doi:10.1016/j.bbrc.2009.03.014. PMID 19275893.
Reissmann E, JÃ¶rnvall H, Blokzijl A, et al. (2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.". Genes Dev. 15 (15): 2010-22. doi:10.1101/gad.201801. PMID 11485994.
Andersson O, Korach-Andre M, Reissmann E, et al. (2008). "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity.". Proc. Natl. Acad. Sci. U.S.A. 105 (20): 7252-6. doi:10.1073/pnas.0800272105. PMID 18480259.
Watanabe R, Shen ZP, Tsuda K, Yamada Y (2008). "Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells.". Biochem. Biophys. Res. Commun. 377 (3): 867-72. doi:10.1016/j.bbrc.2008.10.074. PMID 18951876.
Roberts HJ, Hu S, Qiu Q, et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.". Biol. Reprod. 68 (5): 1719-26. doi:10.1095/biolreprod.102.013045. PMID 12606401.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Xu G, Zhong Y, Munir S, et al. (2004). "Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7.". J. Clin. Endocrinol. Metab. 89 (11): 5523-34. doi:10.1210/jc.2004-0893. PMID 15531507.
Xu G, Bernaudo S, Fu G, et al. (2008). "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7.". Mol. Biol. Cell 19 (11): 4968-79. doi:10.1091/mbc.E08-03-0259. PMID 18784254.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kim BC, van Gelder H, Kim TA, et al. (2004). "Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.". J. Biol. Chem. 279 (27): 28458-65. doi:10.1074/jbc.M313277200. PMID 15107418.
Munir S, Xu G, Wu Y, et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.". J. Biol. Chem. 279 (30): 31277-86. doi:10.1074/jbc.M400641200. PMID 15150278.
Xu G, Zhou H, Wang Q, et al. (2006). "Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines.". Mol. Cancer Res. 4 (4): 235-46. doi:10.1158/1541-7786.MCR-05-0174. PMID 16603637.
Tsuchida K, Nakatani M, Yamakawa N, et al. (2004). "Activin isoforms signal through type I receptor serine/threonine kinase ALK7.". Mol. Cell. Endocrinol. 220 (1-2): 59-65. doi:10.1016/j.mce.2004.03.009. PMID 15196700.

[pmid12063393-0] Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3-4): 157–62. PMID 12063393.

[pmid12065756-1] Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. PMID 12065756.

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