ACP6 Information & ACP6 Links at HealthHaven.com

Acid phosphatase 6, lysophosphatidic
Identifiers
Symbols	ACP6; LPAP; ACPL1; PACPL1
External IDs	MGI: 1931010 HomoloGene: 41128 GeneCards: ACP6 Gene
Gene ontology
Molecular function	• acid phosphatase activity; • hydrolase activity;
Cellular component	• mitochondrion;
Biological process	• lipid metabolic process;
RNA expression pattern
	More reference expression data
Orthologs

edit

Lysophosphatidic acid phosphatase type 6 is an enzyme that in humans is encoded by the ACP6 gene.^[1]^[2]^[3]

[edit] Interactions

ACP6 has been shown to interact with Integrin-linked kinase.^[4]

[edit] References

^ Takayama I, Daigo Y, Ward SM, Sanders KM, Walker RL, Horowitz B, Yamanaka T, Fujino MA (May 2002). "Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum". Gut 50 (6): 790-6. PMID 12010880.
^ Hiroyama M, Takenawa T (Nov 1999). "Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis". J Biol Chem 274 (41): 29172-80. PMID 10506173.
^ "Entrez Gene: ACP6 acid phosphatase 6, lysophosphatidic". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51205.
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3: 89. doi:10.1038/msb4100134. PMID 17353931.

[edit] Further reading

Hiroyama M, Takenawa T (1999). "Purification and characterization of a lysophosphatidic acid-specific phosphatase.". Biochem. J. 336 ( Pt 2): 483–9. PMID 9820827.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tanaka M, Kishi Y, Takanezawa Y, et al. (2004). "Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.". FEBS Lett. 571 (1-3): 197–204. doi:10.1016/j.febslet.2004.06.083. PMID 15280042.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid12010880-0] Takayama I, Daigo Y, Ward SM, Sanders KM, Walker RL, Horowitz B, Yamanaka T, Fujino MA (May 2002). "Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum". Gut 50 (6): 790-6. PMID 12010880.

[pmid10506173-1] Hiroyama M, Takenawa T (Nov 1999). "Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis". J Biol Chem 274 (41): 29172-80. PMID 10506173.

[entrez-2] "Entrez Gene: ACP6 acid phosphatase 6, lysophosphatidic". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51205.

[pmid17353931-3] Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3: 89. doi:10.1038/msb4100134. PMID 17353931.

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