ACOT7 Information & ACOT7 Links at HealthHaven.com

Acyl-CoA thioesterase 7
Identifiers
Symbols	ACOT7; ACT; ACH1; BACH; CTE-II; LACH; LACH1; MGC1126; hBACH
External IDs	OMIM: 602587 MGI: 1917275 HomoloGene: 15780
EC number	3.1.2.2
Gene ontology
Molecular function	• acyl-CoA binding; • carboxylesterase activity; • palmitoyl-CoA hydrolase activity; • hydrolase activity;
Cellular component	• cytoplasm; • mitochondrion;
Biological process	• lipid metabolic process;
RNA expression pattern
	More reference expression data
Orthologs
NP_009205 (protein)	NP_579926 (protein)

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Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.^[1]^[2]^[3]^[4]

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.^[4]

[edit] References

^ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem 126 (6): 1013-9. PMID 10578051.
^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029-32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855-64. doi:10.1096/fj.06-6042com. PMID 16940157.
^ ^a ^b "Entrez Gene: ACOT7 acyl-CoA thioesterase 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11332.

[edit] Further reading

Yamada J (2006). "Long-chain acyl-CoA hydrolase in the brain.". Amino Acids 28 (3): 273–8. doi:10.1007/s00726-005-0181-1. PMID 15731883.
Yamada J, Kuramochi Y, Takagi M, et al. (2003). "Human brain acyl-CoA hydrolase isoforms encoded by a single gene.". Biochem. Biophys. Res. Commun. 299 (1): 49–56. doi:10.1016/S0006-291X(02)02587-1. PMID 12435388.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yang JW, Czech T, Yamada J, et al. (2005). "Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy.". Amino Acids 27 (3-4): 269–75. doi:10.1007/s00726-004-0138-9. PMID 15592755.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid10578051-0] Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem 126 (6): 1013-9. PMID 10578051.

[pmid16103133-1] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029-32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.

[pmid16940157-2] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855-64. doi:10.1096/fj.06-6042com. PMID 16940157.

[entrez-3] "Entrez Gene: ACOT7 acyl-CoA thioesterase 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11332.

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