ACBD3 Information & ACBD3 Links at HealthHaven.com

Acyl-Coenzyme A binding domain containing 3
Identifiers
Symbols	ACBD3; GCP60; GOCAP1; GOLPH1; PAP7
External IDs	OMIM: 606809 MGI: 2181074 HomoloGene: 11227
Gene ontology
Molecular function	• acyl-CoA binding; • binding;
Cellular component	• mitochondrion; • integral to membrane;
Biological process	• steroid biosynthetic process; • transport;
RNA expression pattern
	More reference expression data
Orthologs
NP_073572 (protein)	NP_573488 (protein)

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Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.^[1]

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.^[1]

[edit] Interactions

ACBD3 has been shown to interact with GOLGB1.^[2]

[edit] References

^ ^a ^b "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64746.
^ Sohda, M; Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (Nov. 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. (United States) 276 (48): 45298–306. doi:10.1074/jbc.M108961200. ISSN 0021-9258. PMID 11590181.

[edit] Further reading

Sohda M, Misumi Y, Yamamoto A, et al. (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin.". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. PMID 11590181.
Li H, Degenhardt B, Tobin D, et al. (2002). "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein.". Mol. Endocrinol. 15 (12): 2211–28. doi:10.1210/me.15.12.2211. PMID 11731621.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Liu J, Matyakhina L, Han Z, et al. (2003). "Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues.". Faseb J. 17 (9): 1189–91. doi:10.1096/fj.02-1066fje. PMID 12692076.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment.". J. Biol. Chem. 281 (38): 27924–31. doi:10.1074/jbc.M603276200. PMID 16870622.
Sbodio JI, Machamer CE (2007). "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160.". J. Biol. Chem. 282 (41): 29874–81. doi:10.1074/jbc.M705794200. PMID 17711851.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[entrez-0] "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64746.

[pmid11590181-1] Sohda, M; Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (Nov. 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. (United States) 276 (48): 45298–306. doi:10.1074/jbc.M108961200. ISSN 0021-9258. PMID 11590181.

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