ABL2 Information & ABL2 Links at HealthHaven.com

V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
	PDB rendering based on 1ab2.
Available structures
	1ab2, 1abo, 1abq, 1bbz, 1fpu, 1iep, 1ju5, 1m52, 1opj, 2e2b, 2f4j, 2g1t, 2g2f, 2g2h, 2g2i, 2gqg, 2hiw, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn
Identifiers
Symbols	ABL2; ABLL; ARG
External IDs	OMIM: 164690 MGI: 87860 HomoloGene: 5278
Gene ontology
Molecular function	• nucleotide binding; • magnesium ion binding; • protein-tyrosine kinase activity; • protein binding; • ATP binding; • transferase activity; • manganese ion binding; • phosphoinositide 3-kinase regulator activity;
Cellular component	• cytoplasm; • phosphoinositide 3-kinase complex; • actin cytoskeleton;
Biological process	• cell adhesion; • intracellular signaling cascade; • peptidyl-tyrosine phosphorylation; • actin filament bundle formation;
RNA expression pattern
	More reference expression data
Orthologs
NP_005149 (protein)	NP_033725 (protein)

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Tyrosine-protein kinase ABL2 is an enzyme that in humans is encoded by the ABL2 gene.^[1]^[2]

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.^[2]

[edit] Interactions

ABL2 has been shown to interact with Catalase,^[3] SORBS2^[4] and Abl gene.^[5]

[edit] References

^ Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science 234 (4783): 1545-8. PMID 3787260.
^ ^a ^b "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27.
^ Cao, Cheng; Leng Yumei, Kufe Donald (Aug. 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. Biol. Chem. (United States) 278 (32): 29667-75. doi:10.1074/jbc.M301292200. ISSN 0021-9258. PMID 12777400.
^ Wang, B; Golemis E A, Kruh G D (Jul. 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. (UNITED STATES) 272 (28): 17542-50. ISSN 0021-9258. PMID 9211900.
^ Cao, Cheng; Leng Yumei, Li Chufang, Kufe Donald (Apr. 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. (United States) 278 (15): 12961-7. doi:10.1074/jbc.M300058200. ISSN 0021-9258. PMID 12569093.

[edit] Further reading

Pendergast AM (2003). "The Abl family kinases: mechanisms of regulation and signaling.". Adv. Cancer Res. 85: 51–100. doi:10.1016/S0065-230X(02)85003-5. PMID 12374288.
Muller AJ, Pendergast AM, Havlik MH, et al. (1992). "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.". Mol. Cell. Biol. 12 (11): 5087–93. PMID 1383690.
Kruh GD, Perego R, Miki T, Aaronson SA (1990). "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5802–6. doi:10.1073/pnas.87.15.5802. PMID 2198571.
Kruh GD, King CR, Kraus MH, et al. (1987). "A novel human gene closely related to the abl proto-oncogene.". Science 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase.". Oncogene 13 (1): 193–7. PMID 8700546.
Wang B, Mysliwiec T, Feller SM, et al. (1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk.". Oncogene 13 (7): 1379–85. PMID 8875975.
Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks.". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Koval AP, Blakesley VA, Roberts CT, et al. (1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.". Biochem. J. 330 ( Pt 2): 923–32. PMID 9480911.
Hashimoto Y, Katayama H, Kiyokawa E, et al. (1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.". J. Biol. Chem. 273 (27): 17186–91. doi:10.1074/jbc.273.27.17186. PMID 9642287.
Danial NN, Losman JA, Lu T, et al. (1998). "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.". Mol. Cell. Biol. 18 (11): 6795–804. PMID 9774693.
Cao C, Ren X, Kharbanda S, et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.". J. Biol. Chem. 276 (15): 11465–8. doi:10.1074/jbc.C100050200. PMID 11278261.
Yu HH, Zisch AH, Dodelet VC, Pasquale EB (2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor.". Oncogene 20 (30): 3995–4006. doi:10.1038/sj.onc.1204524. PMID 11494128.
Endo A, Nagashima K, Kurose H, et al. (2002). "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.". J. Biol. Chem. 277 (26): 23747–54. doi:10.1074/jbc.M111794200. PMID 11956190.
Abassi YA, Vuori K (2002). "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.". Embo J. 21 (17): 4571–82. doi:10.1093/emboj/cdf446. PMID 12198159.
Bianchi C, Muradore I, Corizzato M, et al. (2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation.". FEBS Lett. 527 (1-3): 216–222. doi:10.1016/S0014-5793(02)03233-7. PMID 12220663.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMID 12522270.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid3787260-0] Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science 234 (4783): 1545-8. PMID 3787260.

[entrez-1] "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27.

[pmid12777400-2] Cao, Cheng; Leng Yumei, Kufe Donald (Aug. 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. Biol. Chem. (United States) 278 (32): 29667-75. doi:10.1074/jbc.M301292200. ISSN 0021-9258. PMID 12777400.

[pmid9211900-3] Wang, B; Golemis E A, Kruh G D (Jul. 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. (UNITED STATES) 272 (28): 17542-50. ISSN 0021-9258. PMID 9211900.

[pmid12569093-4] Cao, Cheng; Leng Yumei, Li Chufang, Kufe Donald (Apr. 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. (United States) 278 (15): 12961-7. doi:10.1074/jbc.M300058200. ISSN 0021-9258. PMID 12569093.

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