Putative ATP-binding cassette transporter sub-family C member 13 is a protein that in humans is encoded by the ABCC13 gene.[1]
This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.[1]
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- Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates.". Annual review of genomics and human genetics 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
- Annilo T, Dean M (2005). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages.". Genomics 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- Brun ME, Ruault M, Ventura M, et al. (2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms.". Gene 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339.
- Yabuuchi H, Takayanagi S, Yoshinaga K, et al. (2003). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver.". Biochem. Biophys. Res. Commun. 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816.
- Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.". Genomics 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
- Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
- Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum. Mol. Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
