AATK Information & AATK Links at HealthHaven.com

Apoptosis-associated tyrosine kinase
Identifiers
Symbols	AATK; AATYK; KIAA0641; LMR1; LMTK1
External IDs	OMIM: 605276 MGI: 1197518 HomoloGene: 74861 GeneCards: AATK Gene
Gene ontology
Molecular function	• nucleotide binding; • protein serine/threonine kinase activity; • protein-tyrosine kinase activity; • ATP binding; • transferase activity;
Cellular component	• membrane; • integral to membrane;
Biological process	• protein amino acid phosphorylation;
Orthologs

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Serine/threonine-protein kinase LMTK1 is an enzyme that in humans is encoded by the AATK gene.^[1]^[2]^[3]

AATK is a novel gene which is induced during apoptosis. It encodes a protein with a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. AATK expression may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells^[3]

[edit] References

^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169-76. PMID 9734811.
^ Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). "Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization.". J Hum Genet 44 (2): 141-2. PMID 10083745.
^ ^a ^b "Entrez Gene: AATK apoptosis-associated tyrosine kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9625.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Raghunath M, Patti R, Bannerman P, et al. (2000). "A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line.". Brain Res. Mol. Brain Res. 77 (2): 151–62. doi:10.1016/S0169-328X(00)00048-6. PMID 10837911.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tomomura M, Hasegawa Y, Hashikawa T, et al. (2003). "Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain.". Brain Res. Mol. Brain Res. 112 (1-2): 103–12. doi:10.1016/S0169-328X(03)00054-8. PMID 12670708.
Honma N, Asada A, Takeshita S, et al. (2003). "Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.". Biochem. Biophys. Res. Commun. 310 (2): 398–404. doi:10.1016/j.bbrc.2003.08.143. PMID 14521924.
Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.". J. Biol. Chem. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

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[pmid9734811-0] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169-76. PMID 9734811.

[pmid10083745-1] Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). "Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization.". J Hum Genet 44 (2): 141-2. PMID 10083745.

[entrez-2] "Entrez Gene: AATK apoptosis-associated tyrosine kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9625.

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