AAK1 Information & AAK1 Links at HealthHaven.com

AP2 associated kinase 1
Identifiers
Symbols	AAK1; KIAA1048; MGC138170
External IDs	MGI: 1098687 HomoloGene: 75032
Gene ontology
Molecular function	• nucleotide binding; • protein serine/threonine kinase activity; • ATP binding; • transferase activity;
Biological process	• protein amino acid phosphorylation;
RNA expression pattern
	More reference expression data
Orthologs
NP_055726 (protein)	NP_001035195 (protein)

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AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene.^[1]^[2]^[3]

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[3]

[edit] References

^ Conner SD, Schmid SL (Mar 2002). "Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis.". J Cell Biol 156 (5): 921-9. doi:10.1083/jcb.200108123. PMID 11877461.
^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome.". Science 298 (5600): 1912-34. doi:10.1126/science.1075762. PMID 12471243.
^ ^a ^b "Entrez Gene: AAK1 AP2 associated kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848.

[edit] Further reading

Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Ricotta D, Conner SD, Schmid SL, et al. (2002). "Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.". J. Cell Biol. 156 (5): 791–5. doi:10.1083/jcb.200111068. PMID 11877457.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Conner SD, Schmid SL (2003). "Differential requirements for AP-2 in clathrin-mediated endocytosis.". J. Cell Biol. 162 (5): 773–9. doi:10.1083/jcb.200304069. PMID 12952931.
Conner SD, Schröter T, Schmid SL (2004). "AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin.". Traffic 4 (12): 885–90. doi:10.1046/j.1398-9219.2003.0142.x. PMID 14617351.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mishra SK, Hawryluk MJ, Brett TJ, et al. (2004). "Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage.". J. Biol. Chem. 279 (44): 46191–203. doi:10.1074/jbc.M408095200. PMID 15292237.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Collawn JF (2006). "Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key.". Am. J. Respir. Cell Mol. Biol. 35 (1): 1–2. doi:10.1165/rcmb.f317. PMID 16782842.
Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMID 16903783.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Takahashi T, Furuchi T, Naganuma A (2007). "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells.". Cancer Res. 66 (24): 11932–7. doi:10.1158/0008-5472.CAN-06-3220. PMID 17178891.
Henderson DM, Conner SD (2007). "A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.". Mol. Biol. Cell 18 (7): 2698–706. doi:10.1091/mbc.E06-09-0831. PMID 17494869.

This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid11877461-0] Conner SD, Schmid SL (Mar 2002). "Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis.". J Cell Biol 156 (5): 921-9. doi:10.1083/jcb.200108123. PMID 11877461.

[pmid12471243-1] Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome.". Science 298 (5600): 1912-34. doi:10.1126/science.1075762. PMID 12471243.

[entrez-2] "Entrez Gene: AAK1 AP2 associated kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848.

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