AADAC Information & AADAC Links at HealthHaven.com

Arylacetamide deacetylase (esterase)
Identifiers
Symbols	AADAC; CES5A1; DAC
External IDs	OMIM: 600338 MGI: 1915008 HomoloGene: 37436
Gene ontology
Molecular function	• lipase activity; • deacetylase activity;
Cellular component	• endoplasmic reticulum; • endoplasmic reticulum membrane; • microsome; • membrane; • integral to membrane;
Biological process	• metabolic process;
RNA expression pattern
	More reference expression data
Orthologs
NP_001077 (protein)	NP_075872 (protein)

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Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.^[1]^[2]

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens^[2]

[edit] References

^ Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.". J Biol Chem 269 (34): 21650-6. PMID 8063807.
^ ^a ^b "Entrez Gene: AADAC arylacetamide deacetylase (esterase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=13.

[edit] Further reading

Probst MR, Jenö P, Meyer UA (1991). "Purification and characterization of a human liver arylacetamide deacetylase.". Biochem. Biophys. Res. Commun. 177 (1): 453–9. doi:10.1016/0006-291X(91)92005-5. PMID 2043131.
Yamazaki K, Kusano K, Tadano K, Tanaka I (1997). "Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3.". Genomics 44 (2): 248–50. doi:10.1006/geno.1997.4879. PMID 9299245.
Ozols J (1998). "Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase.". Biochemistry 37 (28): 10336–44. doi:10.1021/bi9807916. PMID 9665742.
Mziaut H, Korza G, Hand AR, et al. (1999). "Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase.". J. Biol. Chem. 274 (20): 14122–9. doi:10.1074/jbc.274.20.14122. PMID 10318829.
Trickett JI, Patel DD, Knight BL, et al. (2001). "Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.". J. Biol. Chem. 276 (43): 39522–32. doi:10.1074/jbc.M101764200. PMID 11481320.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID 12721789.
Frick C, Atanasov AG, Arnold P, et al. (2004). "Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.". J. Biol. Chem. 279 (30): 31131–8. doi:10.1074/jbc.M313666200. PMID 15152005.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid8063807-0] Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.". J Biol Chem 269 (34): 21650-6. PMID 8063807.

[entrez-1] "Entrez Gene: AADAC arylacetamide deacetylase (esterase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=13.

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