Atomic structure of the 50S Subunit from Haloarcula marismortui. Proteins are shown in blue and the two RNA strands in orange and yellow.^[1] The small patch of green in the center of the subunit is the active site.

Atomic structure of the 50S Large Subunit of the Ribosome. Proteins are colored in blue and RNA in orange. The active site, adenine 2486 is colored in red. Image created from PDB id, 1s72 using PyMol

50S is the larger subunit of the 70S ribosome of prokaryotes.

It is the site of inhibition for antibiotics such as chloramphenicol, clindamycin and the pleuromutilins.

It includes the subunits 5S and 23S.

[edit] See also

• 30S
• Ribosomal RNA

[edit] References

1. ^ Ban N, Nissen P, Hansen J, Moore P, Steitz T (2000). "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution". Science 289 (5481): 905–20. doi:10.1126/science.289.5481.905. PMID 10937989. 

[edit] External links

• http://pathmicro.med.sc.edu/mayer/antibiot.htm
• http://www.molgen.mpg.de/~ag_ribo/ag_franceschi/franceschi-projects-50S-antibiotics.html
• http://riboworld.com/antib/50santib-eng.shtml
• MeSH 23S+Ribosomal+RNA
• MeSH 5S+Ribosomal+RNA

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