5-HT1F receptor Information & 5-HT1F receptor Links at HealthHaven.com

5-hydroxytryptamine (serotonin) receptor 1F
Identifiers
Symbols	HTR1F; 5-HT1F; HTR1EL; MR77
External IDs	OMIM: 182134 MGI: 99842 HomoloGene: 37361 IUPHAR: 5-HT1F GeneCards: HTR1F Gene
Gene ontology
Molecular function	• rhodopsin-like receptor activity; • receptor activity; • serotonin receptor activity;
Cellular component	• integral to plasma membrane; • membrane;
Biological process	• signal transduction; • G-protein signaling, coupled to cyclic nucleotide second messenger; • synaptic transmission;
RNA expression pattern
	More reference expression data
Orthologs

edit

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT₁ receptor protein and also denotes the human gene encoding it.^[1]^[2]^[3]^[4]^[5]

[edit] Ligands

[edit] Agonists

Eletriptan - mixed 5-HT_{1B/1D/1E/1F/2B/7} agonist
LY-334,370^[6] - as well as related benzamides^[7]
LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
Naratriptan - mixed 5-HT_1B/1D/1F agonist

[edit] Antagonists

No selective 5HT_1F antagonists are available as yet.

[edit] See also

[edit] References

^ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3355.
^ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (January 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408–12. doi:10.1073/pnas.90.2.408. PMID 8380639. PMC 45671. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8380639.
^ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (March 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184–8. doi:10.1073/pnas.90.6.2184. PMID 8384716. PMC 46050. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8384716.
^ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Mol. Membr. Biol. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.
^ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (June 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". Am. J. Med. Genet. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.
^ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). "[³H]-LY-334,370, a novel radioligand for the 5-HT_1F receptor. I. In vitro characterization of binding properties". Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510.
^ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT_1F receptor agonists". Bioorg. Med. Chem. Lett. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.

[edit] External links

"5-HT_1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2318.

[edit] Further reading

Hoyer D, Hannon JP, Martin GR (2002). "Molecular, pharmacological and functional diversity of 5-HT receptors.". Pharmacol. Biochem. Behav. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546.
Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
Amlaiky N, Ramboz S, Boschert U, et al. (1992). "Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus.". J. Biol. Chem. 267 (28): 19761–4. PMID 1328180.
Adham N, Kao HT, Schecter LE, et al. (1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408–12. doi:10.1073/pnas.90.2.408. PMID 8380639.
Lovenberg TW, Erlander MG, Baron BM, et al. (1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184–8. doi:10.1073/pnas.90.6.2184. PMID 8384716.
Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, et al. (1999). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients.". Am. J. Med. Genet. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bhatnagar A, Sheffler DJ, Kroeze WK, et al. (2004). "Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors.". J. Biol. Chem. 279 (33): 34614–23. doi:10.1074/jbc.M404673200. PMID 15190056.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, et al. (2006). "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia.". PLoS Genet. 1 (4): e50. doi:10.1371/journal.pgen.0010050. PMID 16254601.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[entrez-0] "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3355.

[pmid8380639-1] Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (January 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408–12. doi:10.1073/pnas.90.2.408. PMID 8380639. PMC 45671. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8380639.

[pmid8384716-2] Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (March 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184–8. doi:10.1073/pnas.90.6.2184. PMID 8384716. PMC 46050. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8384716.

[pmid9394293-3] Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Mol. Membr. Biol. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.

[pmid9632173-4] Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (June 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". Am. J. Med. Genet. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.

[pmid15900510-5] Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). "[³H]-LY-334,370, a novel radioligand for the 5-HT_1F receptor. I. In vitro characterization of binding properties". Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510.

[pmid15546719-6] Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT_1F receptor agonists". Bioorg. Med. Chem. Lett. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.

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